Acute posterior multifocal placoid pigment epitheliopathy and scleritis in a patient with pANCA-positive systemic vasculitis

American Journal of Ophthalmology
Toshihiko MatsuoChieko Nagai

Abstract

To present acute posterior multifocal placoid pigment epitheliopathy and scleritis occurring in association with pANCA (perinuclear antineutrophil cytoplasmic antibody)-positive systemic vasculitis. Interventional case report. A 69-year-old woman developed bilateral acute posterior multifocal placoid pigment epitheliopathy concurrent with rapidly progressive glomerulonephritis and bronchioalveolitis in both lungs. The patient showed a high titer of pANCA (myeloperoxidase-ANCA). She then developed scleritis in the left eye and multiple gastric ulcers. Acute posterior multifocal placoid pigment epitheliopathy and scleritis in this patient are manifestations that are part of pANCA-positive systemic vasculitis. This association further supports that acute posterior multifocal placoid pigment epitheliopathy is caused by vasculitic inflammation of the choriocapillaris.

References

Apr 1, 1995·The British Journal of Ophthalmology·N P Jones
Jun 12, 1999·Respiration; International Review of Thoracic Diseases·Y Sugiyama, S Kitamura

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Citations

Nov 22, 2007·The American Journal of the Medical Sciences·Akinori HaraShuichi Kaneko
Nov 20, 2015·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Hashim Ali Khan, Muhammad Aamir Shahzad
Oct 31, 2013·European Journal of Ophthalmology·Gilda CennamoGiuseppe De Crecchio
Jan 19, 2018·Neuro-ophthalmology·Padmaja SudhakarSachin Kedar
Jun 21, 2013·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Benjamin K-T TsangCatriona McLean
Sep 8, 2012·International Ophthalmology Clinics·Scott Steiner, Debra A Goldstein
Jul 20, 2021·American Journal of Ophthalmology Case Reports·Thérèse M SassalosChristopher D Conrady

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