Acute postprandial lipaemia does not influence the in vivo activity of human platelets

Thrombosis Research
J A JakubowskiF J Morgan

Abstract

Platelet function and serum lipid studies were conducted on nine healthy male subjects before and two hours after three separate meals, two of which were rich in fat: saturated fat (SF) or polyunsaturated fat (PUF), and a third control meal which contained no fat. Platelet activity was assessed by determination of in vivo platelet aggregate formation, and plasma levels of the platelet specific proteins platelet factor 4 (PF4) and beta-thromboglobulin (beta-TG). Serum triglyceride levels increased significantly after both fat containing meals but were unaffected by the fat free meal. Serum cholesterol levels were not affected by any of the three meals. Platelet function tests could not detect any alteration of in vivo platelet activity in terms of platelet aggregate formation or plasma concentrations of PF4 and beta-TG. These results are at variance with previously published studies that used less specific assays of platelet activity and which suggested platelet activation shortly after meals rich in SF.

References

Jun 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·J HawigerR G Horn

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Citations

Jan 18, 2003·Lipids·Yongsoon Park, William Harris
Oct 4, 2003·Current Atherosclerosis Reports·Dianne HysonLars Berglund
Aug 14, 1995·Clinica Chimica Acta; International Journal of Clinical Chemistry·R KnöflerA Takada
Nov 13, 2001·European Journal of Ultrasound : Official Journal of the European Federation of Societies for Ultrasound in Medicine and Biology·C OttoH Schmid-Schönbein
Mar 3, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Sabina Paglialunga, Katherine Cianflone
Jul 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J NimpfG M Kostner
Jul 18, 2002·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Dianne A HysonJohn C Rutledge
Jun 20, 2018·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Joyce P M KrekelsYvonne M C Henskens

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