PMID: 18719319Aug 23, 2008Paper

Acute protective effects of simvastatin in the rat model of renal ischemia-reperfusion injury: it is never too late for the pretreatment

Journal of Pharmacological Sciences
Zoran TodorovićMilica Prostran

Abstract

Acute pretreatment with a single i.v. bolus injection of simvastatin (1 mg/kg) significantly protects rat kidney injured by ischemia-reperfusion (I/R) (45 min + 6 h). We aimed to determine the optimal timing of such a pretreatment. The effects of both injections of simvastatin before ischemia and reperfusion were similar regarding total histological score. However, simvastatin injected 30 min before ischemia was 30% - 75% more effective in reduction of serum creatinine levels and interstitial edema score, while its injections 5 and 30 min before reperfusion were 25% - 60% more effective in reduction of tubular necrosis score and fractional excretion of Na+. However, the observed differences do not seem to offer significant advantage in clinical settings.

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Citations

Apr 1, 2014·PloS One·Zoran TodorovicMilica Prostran
Oct 27, 2009·Pediatric Surgery International·Nadav SlijperJorge Mogilner
Mar 27, 2012·Journal of Cardiothoracic and Vascular Anesthesia·Jinyoung HwangSunghee Han
Jul 20, 2010·The Journal of Urology·Stone YangChun-Jen Huang
Dec 24, 2014·The Journal of Surgical Research·Chen-Hsien YangChun-Jen Huang
Jun 14, 2016·Clinical and Experimental Nephrology·Tadashi Yoshida, Matsuhiko Hayashi
Jul 5, 2012·Acta Cirúrgica Brasileira·Silvio Tucci JuniorAntonio Carlos Pereira Martins
Jun 25, 2010·Cell Transplantation·Hiroshi YagiMartin L Yarmush
Jan 8, 2018·Turkish Journal of Medical Sciences·Demet AcarBaşar Cander
Apr 4, 2021·International Journal of Molecular Sciences·Zoran TodorovićJelena Đorđević

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