Acute pulmonary artery hypertension produced by distention of the main pulmonary artery in the conscious dog.

Chest
M M LaksJ M Criley

Abstract

In order to delineate further the function of the main pulmonary artery as a receptor site, a specially designed Laks triple-lumen balloon catheter was inserted transvenously and positioned in the main pulmonary artery. In six conscious nonsedated dogs, inflation of a balloon in the main pulmonary artery produced acute reversible pulmonary arterial hypertension; the pressure beyond the balloon increased from a mean of 21/6 mm Hg to 43/14 mm Hg (P less than 0,001). This observed pulmonary hypertension occurred at an amount of balloon inflation which produced an increase in right ventricular systolic pressure (P less than 0.001), but no significant change occurred in cardiac output (P greater than 0.05) or right ventricular end-diastolic pressure (P greater than 0.1). Left atrial and pulmonary artery wedge pressures did not change or decreased slightly (P greater than 0.1 and P greater than 0.1, respectively). The calculated pulmonary vascular resistance increased (P less than 0.001), while the calculated systemic vascular resistance did not chang (P greater than 0.04). Therefore, we postulate that distention of the main pulmonary artery in the conscious dog reflexly produces constriction of pulmonary arterioles, and possibly ven...Continue Reading

References

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Citations

Jan 1, 1990·The American Review of Respiratory Disease·K M Moser
Jan 1, 1992·The American Review of Respiratory Disease·G Manier, Y Castaing
Mar 8, 2013·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Shao-Liang ChenTak W Kwan
Jun 14, 2013·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Yao-Jun ZhangShao-Liang Chen
Jan 23, 2015·Pulmonary Circulation·Thomas J Kulik
Oct 1, 1985·The American Journal of Cardiology·J M Milstein, B W Goetzman
Dec 10, 2013·Journal of the American College of Cardiology·Paul Bhamra-ArizaDavid W M Muller
Mar 1, 1984·The American Journal of Physiology·W J RaumM M Laks
Apr 1, 1992·Chest·C G Elliott

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