Acute Q Fever Endocarditis: A Paradigm Shift Following the Systematic Use of Transthoracic Echocardiography During Acute Q Fever

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Cléa MelenotteD Raoult

Abstract

As Q fever, caused by Coxiella burnetii, is a major health challenge due to its cardiovascular complications, we aimed to detect acute Q fever valvular injury to improve therapeutic management. In the French national reference center for Q fever, we prospectively collected data from patients with acute Q fever and valvular injury. We identified a new clinical entity, acute Q fever endocarditis, defined as valvular lesion potentially caused by C. burnetii: vegetation, valvular nodular thickening, rupture of chorda tendinae, and valve or chorda tendinae thickness. To determine whether or not the disease was superimposed on an underlying valvulopathy, patients' physicians were contacted. Aortic bicuspidy, valvular stenosis, and insufficiency were considered as underlying valvulopathies. Of the 2434 patients treated in our center, 1797 had acute Q fever and 48 had acute Q fever endocarditis. In 35 cases (72%), transthoracic echocardiography (TTE) identified a valvular lesion of acute Q fever endocarditis without underlying valvulopathy. Positive anticardiolipin antibodies (>22 immunoglobulin G-type phospholipid units [GPLU]) were independently associated with acute Q fever endocarditis (odds ratio [OR], 2.7 [95% confidence interval...Continue Reading

References

Dec 25, 1982·Lancet·S R Palmer, S E Young
Feb 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J Ordi-RosM Vilardell-Tarres
Jul 3, 1998·Journal of Clinical Microbiology·P E FournierD Raoult
Jul 5, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F FenollarD Raoult
Jan 25, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pierre HoupikianDidier Raoult
Apr 25, 1959·Lancet·A D EVANSC D BURRELL
Nov 14, 1959·British Medical Journal·A O ROBSON, C D SHIMMIN
Mar 29, 2005·The Lancet Infectious Diseases·D RaoultJl Mege
Feb 16, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Florence FenollarDidier Raoult
Mar 11, 2009·Archives of Internal Medicine·David R MurdochUNKNOWN International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS) Investigators
Mar 13, 2010·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Gilbert HabibUNKNOWN European Association of Echocardiography
Jul 20, 2010·The Lancet Infectious Diseases·Matthieu MillionDidier Raoult
Mar 28, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Matthieu MillionDidier Raoult
Jun 5, 2013·European Heart Journal Cardiovascular Imaging·Patrizio LancellottiUNKNOWN Scientific Document Committee of the European Association of Cardiovascular Imaging
Jun 25, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Matthieu MillionDidier Raoult
Nov 21, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Matthieu MillionDidier Raoult
Nov 20, 2016·Clinical Microbiology Reviews·Carole EldinDidier Raoult
Feb 12, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C ZaratzianD Raoult
May 6, 2017·Journal of the American College of Cardiology·Michel T CorbanAmir Lerman
Feb 23, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marit M A de LangePeter M Schneeberger
Dec 14, 2018·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S E van RoedenJ J Oosterheert

❮ Previous
Next ❯

Citations

Nov 30, 2019·Expert Review of Anti-infective Therapy·Cléa MelenotteDidier Raoult
Sep 19, 2020·Emerging Infectious Diseases·Ioulia KarageorgouEmmanouil Angelakis
Mar 3, 2019·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C MelenotteD Raoult
Jun 1, 2021·Journal of Medical Imaging and Radiation Oncology·Pirathaban SivabalanRobert Norton
Jun 22, 2021·Emerging Infectious Diseases·Mathilde PugesCharles Cazanave
Oct 10, 2021·Zoonoses and Public Health·Cara C CherryGilbert J Kersh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Matthieu MillionDidier Raoult
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Matthieu MillionDidier Raoult
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Matthieu MillionDidier Raoult
Nihon saikingaku zasshi. Japanese journal of bacteriology
H Oda, K Yoshiie
© 2022 Meta ULC. All rights reserved