Acute rejection after liver transplantation is less common, but predicts better prognosis in HBV-related hepatocellular carcinoma patients.

Hepatology International
Jia-Xi MaoGuo-Shan Ding

Abstract

With a novel finding of significantly lower incidence of acute rejection (AR) in patients with hepatocellular carcinoma (HCC) after liver transplantation, compared with those with benign end-stage liver disease (BESLD), in a large national cohort, we analyzed the correlations among the perioperative immuno-inflammation status, postoperative AR, and prognosis in HCC and BESLD patients with same etiology of hepatitis B virus (HBV), who underwent liver transplantation. Patients who underwent liver transplantation due to HBV-related HCC or BESLD and experienced AR between September 2008 and April 2017 were analyzed retrospectively and followed up until April 2018. HCC patients with AR were matched with those without AR according to tumor stage and immunosuppressant concentration, at a 1:3 ratio. Preoperative immuno-inflammation status and prognosis of patients in both groups were compared. The overall incidences of AR in patients with HCC and BESLD were 8.60% and 10.61%, respectively. The postoperative 28-day incidence of AR was significantly lower in HCC compared with BESLD patients (3.23% vs 7.08%, p = 0.031). Compared with BESLD patients, the rejection activity index and perioperative CD4/CD8 ratio were significantly lower (p = ...Continue Reading

References

Mar 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Montserrat Garcia-RetortilloJuan Rodes
Mar 17, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J T CarterP G Stock
Oct 1, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Mario Fernández-RuizJose María Aguado
Oct 26, 2010·Nature Reviews. Immunology·Angus W Thomson, Percy A Knolle
Dec 14, 2011·Current Opinion in Organ Transplantation·Isa F Ashoor, Nader Najafian
Mar 2, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jimmy K StaufferRobert H Wiltrout
Feb 13, 2014·Immunological Reviews·Daniel N MoriDaniel R Goldstein
Mar 22, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Mario Fernández-RuizJosé M Aguado
May 2, 2014·Frontiers in Immunology·Ole Audun Werner HaabethBjarne Bogen
Sep 11, 2014·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Natalie E NierenbergDavid R Snydman
Jun 19, 2015·Cell Death & Disease·Y JiangB Zhu
Jul 26, 2015·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Sandra A CalarotaFausto Baldanti
Nov 20, 2015·BioMed Research International·Tiffany Caza, Steve Landas
Aug 22, 2016·Current Opinion in Immunology·Anne M PesenackerMegan K Levings
Feb 10, 2017·Nature·Gökhan S Hotamisligil
May 12, 2017·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Fanzhi MengBin Song
Feb 13, 2018·Proceedings of the National Academy of Sciences of the United States of America·Sam PalmerT J Newman
May 10, 2018·World Journal of Gastroenterology : WJG·Naofumi Mukaida, Yasunari Nakamoto
Jun 13, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Yohei ManoYoshihiko Maehara
Jul 28, 2018·The American Journal of the Medical Sciences·Qiang WeiShusen Zheng
Oct 24, 2018·Cancer Biomarkers : Section a of Disease Markers·Baofeng MaZhaoxiao Yu
Dec 7, 2018·The Journal of Surgical Research·Yoshito YamadaWolfgang Jungraithmayr
Jun 4, 2019·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Quirino LaiJan Lerut

❮ Previous
Next ❯

Citations

Oct 6, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stalin ChellappaEinar Martin Aandahl

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.