PMID: 7940707Oct 15, 1994Paper

Acute rejection of porcine small bowel allograft. An extended histological scoring system

Transplantation
P KuusanmäkiP Häyry

Abstract

Using nonimmunosuppressed piglet small bowel grafts, we performed a detailed histological study on acute rejection and analyzed altogether 45 different histological parameters throughout the bowel wall, in 10 allografts and 6 autografts. Heterotopic grafts were followed by full-thickness biopsies every other day beginning on the 3rd day after transplantation. The parameters were scored from 0 to 3 according to the severity of the change and the values of every variable were compared statistically between the 2 groups. The earliest significant changes, beginning on days 3-5, were infiltration of inflammatory cells and pyroninophilia among these cells in lamina propria; edema, fibrosis, and inflammation in submucosa and muscularis; vacuolar degeneration of myocytes; and endothelial and intimal changes in vessels. Villous blunting and cuboidal epithelium were the other early markers. On day 7, the epithelial and vascular changes became most significant. We want to emphasize especially the vascular parameters: endothelial swelling and proliferation, intimal thickening, intramural inflammation, and obliteration of the lumen. The dilatation of lymph vessels and changes of Peyer's patches had no value in the estimation of rejection. A...Continue Reading

Citations

Nov 20, 1997·Transplantation Proceedings·H U KlehrD Heimbach
Feb 22, 2002·BJU International·A A Shokeir
Jun 29, 2007·Tissue Engineering·Herman TolboomMartin L Yarmush
Apr 1, 2010·Langenbeck's Archives of Surgery·Wei WeiJieshou Li
Feb 16, 2007·Pediatric Transplantation·Hao MaJieshou Li
May 24, 2007·Tissue Engineering·Kazuyoshi IijimaOsamu Nishizawa
Apr 15, 1997·Transplantation·A FayyaziH J Radzun
Feb 23, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Silvio NadalinMassimo Malagó
Oct 13, 2006·Current Opinion in Urology·S R Aboseif, E A Tanagho

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