PMID: 11910227Mar 23, 2002Paper

Acute renal failure during dextran-40 antithrombotic prophylaxis: report of two microsurgical cases

Annals of Plastic Surgery
Sanne C B VosRobert P Noordanus

Abstract

Dextran is often used to enhance the successful outcome of microvascular transplantations. So far, some 60 cases of dextran-induced acute renal failure have been reported. Among them, only one has been reported as an adverse reaction to antithrombotic prophylaxis during microvascular surgery. To stress that dextran prophylaxis can be a serious threat to microsurgical patients, the authors report on two more such patients and discuss how to prevent and treat this condition. Hypovolemic patients of older age are at risk, as are patients with cardiovascular diseases, renal artery stenosis, and preexisting renal insufficiency. Dextran should be discontinued promptly in patients with decreased urinary output or with high urine specific gravity. Dextran-induced acute renal failure may be severe and it may last several days. Plasmapheresis is the therapy of choice and, usually, diuresis and renal function resume shortly after such treatment.

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Citations

Apr 1, 2015·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·J E SwartzW W Braunius
Feb 26, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Michael DickenmannMichael J Mihatsch
Mar 26, 2016·Frontiers in Pharmacology·Emilia SokolowskaAndrzej Mogielnicki
Mar 29, 2014·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·John J LopezDon Westerhausen
May 23, 2006·The Journal of Hand Surgery·Morad AskariW P Andrew Lee
Apr 4, 2013·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·D FroemelJ H Barker
May 26, 2006·European Journal of Anaesthesiology·I J Davidson
Jun 11, 2009·Anesthesiology·Martin WestphalHugo Van Aken

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