Acute renal failure in paediatric systemic lupus erythematosus: treatment and outcome

Rheumatology
Susanne BenselerEarl D Silverman

Abstract

To determine the outcome of paediatric SLE (pSLE) patients with nephritis who developed acute renal failure (ARF). Efficacy and safety of treatment regimens were compared. A total of 249 pSLE patients were diagnosed and prospectively followed at a single centre between July 1973 and July 2003; 127 children (51%) had lupus nephritis. ARF was defined as serum creatinine of > 250 micromol/l or > 75% above baseline. Standardized assessments included clinical data and medications, laboratory testing, disease activity and damage scores were obtained. Subsequent renal flares were documented. renal function at last follow-up. treatment efficacy and safety. AZA- and cyclophosphamide (CYCLO)-treated patients were compared. Propensity score methods were applied to balance covariates. An intention to treat approach was chosen. The ARF study cohort included 50 patients; 13 boys and 37 girls with a median age of 13.2 yrs at diagnosis and a mean follow-up of 45 months. Renal histology: Class III nephritis in 16; Class IV in 34. Dialysis requirement and disease activity were similar in both groups. AZA in 33 patients, CYCLO in 9 and corticosteroids only in 8. no statistically significant or clinically relevant differences were found for any of...Continue Reading

References

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Citations

May 14, 2016·Acta Clinica Belgica·Martine T P BesouwJo L Dehoorne
May 1, 2013·Lupus·P Vachvanichsanong, E McNeil
Dec 4, 2012·The Journal of Rheumatology·Lily Siok Hoon Lim, Brian M Feldman
Jun 21, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Daniel C CattranStéphan Troyanov
Jan 29, 2010·Clinical Reviews in Allergy & Immunology·Stella NtaliDimitrios T Boumpas
Dec 28, 2012·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·Kyoko MarutaHidetoshi Fukunaga
Aug 20, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shin-Ruen YangShuk-Man Ka
Jun 17, 2011·American Journal of Physiology. Renal Physiology·Pei-Yi TsaiAnn Chen

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