Acute renal injury following methanol poisoning: analysis of a case series

International Journal of Toxicology
David VerhelstP Hantson

Abstract

The objective of this paper is to document the prevalence of indicators of acute renal injury in a series of methanol-poisoned patients treated in an intensive care unit and to discuss the possible mechanisms. This is a retrospective analysis of the medical records of 25 consecutive patients admitted to the intensive care unit after severe intentional methanol poisoning. Acute renal impairment was defined as a serum creatinine concentration higher than 177 micro mol/L and/or a urinary output on admission and for the first 24 h below 0.5 ml/kg/h. Clinical pathological signs of acute renal injury were found in 15 patients. In comparison with the 10 other patients taken as control group, the patients who developed renal injury had a lower blood pH value on admission, a higher serum osmolality, and a higher peak formate concentration. Two factors contributing to renal injury could be identified: hemolysis and myoglobinuria. The role of osmotic changes (osmotic nephrosis) or of a direct cytotoxic effect of formic acid remains speculative. Analysis of proteinuria suggests that proximal tubular cells may be preferentially affected. Results of histopathological evaluation of the kidney on a limited sample size (n = 5) were inconclusive...Continue Reading

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Citations

Mar 20, 2013·European Journal of Clinical Pharmacology·Hesamoddin HosseinjaniHossein Khalili
Jul 10, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Olivier DésyPedro O de Campos-Lima
Oct 3, 2013·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Tomas SalekPetr Ponizil
Sep 25, 2012·Critical Care Clinics·James A Kruse
Feb 26, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Michael DickenmannMichael J Mihatsch
Sep 18, 2007·Journal of Forensic Sciences·Graham R JonesKatherine Rittenbach
Jun 7, 2019·BMC Nephrology·Shu-Ting ChangTzung-Hai Yen
Oct 13, 2020·Movement Disorders Clinical Practice·Suvorit S Bhowmick, Anthony E Lang
Jan 27, 2021·Hospital Practice·Charat ThongprayoonWisit Cheungpasitporn
Jun 23, 2021·Environmental Science and Pollution Research International·Asmaa Fady SharifKhalid Abdulmohsen Al-Mulhim
Jun 19, 2021·Annals of Medicine and Surgery·Zahra NekoukarSepideh Safanavaei

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