Acute reproductive toxicology after intratesticular injection of silver nanoparticles (AgNPs) in Wistar rats

Nanotoxicology
Juliana Lis Mendes de BritoCarolina Madeira Lucci

Abstract

This study aimed to evaluate the effects of an intratesticular injection of silver nanoparticles (AgNPs) on reproductive parameters and health of rats, and to evaluate the AgNPs biodistribution in order to develop a nanotechnological contraceptive agent for male animals. Treated animals received 220 μL of AgNPs solution (0.46 µg-Ag/ml) in each testicle and were euthanized: seven, 14, 28, and 56 days after injection. A significant decrease (p < 0.05) in the percentage of motile sperm in D7 (8.8%) was observed, comparing to the control (73.3%), D14 (86.0%), D28 (68.2%), and D56 (90.0%) groups. D7 group also presented a decrease (p < 0.05) in the percentage of normal spermatozoa. Additionally, D7 group showed an increase (p < 0.05) in abnormal midpiece and sperm head morphology compared to the Control group. Seminiferous tubules presented all germline cell types and spermatozoa for all groups. However, D7 group did not present spermatozoa in the epididymis, whereas some spermatozoa and cellular debris were visible in D14 and D28 groups. All animals presented hematological parameters, creatinine, and alanine aminotransferase values within the normal limits for Wistar rats. The percentage of silver found in the liver was always high...Continue Reading

References

Sep 1, 1989·Australian Veterinary Journal·G FordyceR K Shepherd
Mar 22, 2001·Preventive Veterinary Medicine·M R Slater
Feb 1, 1965·Journal of Reproduction and Fertility·A B KARA GOSWAMI
Dec 1, 1961·Endocrinology·A B KAR
Jul 15, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Laura Braydich-StolleMarie-Claude Hofmann
Jan 3, 2008·American Journal of Veterinary Research·Julie K LevyEmma L Clifford
Nov 27, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jae Hyuck SungIl Je Yu
Feb 3, 2009·Experimental and Molecular Pathology·Rajesh Singh, James W Lillard
Oct 8, 2009·Analytica Chimica Acta·Shailini AshokaMalcolm R Reid
May 22, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Laura K Braydich-StolleMarie-Claude Hofmann
Jul 6, 2010·Reproductive Toxicology·Makoto EmaJunko Nakanishi
Aug 10, 2010·Particle and Fibre Toxicology·Yong Soon KimIl Je Yu
Apr 7, 2011·Archives of Pharmacal Research·Kwangsik ParkByung Chun Lee
Jun 15, 2012·Journal of Applied Toxicology : JAT·K DziendzikowskaM Kruszewski
Sep 18, 2012·Toxicology Letters·Joanna Gromadzka-OstrowskaMarcin Kruszewski
Mar 19, 2014·Chinese Journal of Natural Medicines·Dan LiuJing-Yu Liang
Nov 5, 2014·Metallomics : Integrated Biometal Science·Javier Jiménez-LamanaJoanna Szpunar
Mar 4, 2015·International Journal of Nanomedicine·Xi-Feng ZhangJin-Hoi Kim
May 1, 2014·Spermatogenesis·Wilma De Grava Kempinas, Gary Robert Klinefelter
Feb 24, 2016·Reproductive Toxicology·D LafuenteM Gómez
Nov 28, 2017·Scientific Reports·Jakarwan YostawonkulTeerapong Yata
Apr 21, 2018·Journal of Hazardous Materials·Paolin Rocio Cáceres-VélezRicardo Bentes Azevedo
Aug 23, 2018·Reproduction in Domestic Animals = Zuchthygiene·Renata C A SilvaFabiana F Souza
Sep 2, 2018·Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University·Nasibeh FathiMaryam Bahmanzadeh

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