Acute reserpine administration elicits long-term spontaneous oral dyskinesia

European Journal of Pharmacology
A N SussmanJ L Neisewander

Abstract

Chronic reserpine administration produces persistent oral dyskinesia accompanied by severe dopamine depletion in the caudate-putamen. The present study examined whether these behavioral and neurochemical effects would persist following acute reserpine administration. Acute administration of reserpine (1 mg/kg, s.c.) produced spontaneous oral dyskinesia that persisted above control levels for at least 84 days. Reserpine also produced a 74% depletion of dopamine in the caudate-putamen relative to vehicle treatment at 3 days post-injection, but did not significantly alter dopamine in the caudate-putamen at 84 days post-injection. The finding that reserpine-induced oral dyskinesia persisted despite repletion of dopamine in the caudate-putamen suggests that the persistent neuropathological change underlying this behavior occurs in a neural pathway other than the dopaminergic nigrostriatal pathway.

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Citations

Mar 26, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·V G EvidenteC H Alder
May 9, 2002·Behavioural Brain Research·Regina H SilvaRoberto Frussa-Filho
Feb 2, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Patricia R V CalventeFilho Roberto Frussa
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Jul 30, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Jeane Binotto ReinheimerRoselei Fachinetto

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