PMID: 2182300Apr 1, 1990

Acute respiratory and cardiovascular effects of inhaled ketanserin in chronic obstructive pulmonary disease. A comparative study with intravenously administered ketanserin

Mario CazzolaG D'Amato


In a double-blind, crossover study, nebulized ketanserin, a 5-HT2 receptor antagonist, and a placebo were given to eight patients with moderate to severe nonasthmatic COPD. Intravenous ketanserin had rapid onset of action and induced a longer lasting bronchial response than inhaled ketanserin. These results confirm that ketanserin acts as a mild bronchodilator in patients with COPD and demonstrate that the inhaled route has no advantage over the intravenous route in terms of effectiveness. Thus, 5-HT may play a role in bronchomotor tone, at least in patients with chronic airway obstruction.


Jun 1, 1995·Journal of Clinical Pharmacology·W H FrishmanB Shareef
Nov 4, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Way Kwok Wai LauJudith Choi Wo Mak
Jan 1, 1995·Allergy·Mario CazzolaF Rossi
Nov 21, 2007·Pulmonary Pharmacology & Therapeutics·Romain PauwelsEmiel F M Wouters


Jan 1, 1988·European Journal of Clinical Pharmacology·D J StottS G Ball
Oct 1, 1986·British Journal of Clinical Pharmacology·M J CushleyS T Holgate
Apr 1, 1972·Angiology·S Rodbard, S Kira
Oct 1, 1962·Der Tuberkulosearzt·W LUECKERATH

Related Concepts

Inhalation of Drugs
Intravenous Injections
Diastolic Blood Pressure
Forced Expiratory Flow Rates
Controlled Clinical Trials, Randomized
Lung Diseases, Obstructive
Forced Expiratory Volume Function
Chronic Obstructive Airway Disease

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