PMID: 2182300Apr 1, 1990

Acute respiratory and cardiovascular effects of inhaled ketanserin in chronic obstructive pulmonary disease. A comparative study with intravenously administered ketanserin

Chest
Mario CazzolaG D'Amato

Abstract

In a double-blind, crossover study, nebulized ketanserin, a 5-HT2 receptor antagonist, and a placebo were given to eight patients with moderate to severe nonasthmatic COPD. Intravenous ketanserin had rapid onset of action and induced a longer lasting bronchial response than inhaled ketanserin. These results confirm that ketanserin acts as a mild bronchodilator in patients with COPD and demonstrate that the inhaled route has no advantage over the intravenous route in terms of effectiveness. Thus, 5-HT may play a role in bronchomotor tone, at least in patients with chronic airway obstruction.

References

Jun 1, 1995·Journal of Clinical Pharmacology·W H FrishmanB Shareef
Nov 4, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Way Kwok Wai LauJudith Choi Wo Mak
Jan 1, 1995·Allergy·Mario CazzolaF Rossi
Nov 21, 2007·Pulmonary Pharmacology & Therapeutics·Romain PauwelsEmiel F M Wouters

Citations

Jan 1, 1988·European Journal of Clinical Pharmacology·D J StottS G Ball
Oct 1, 1986·British Journal of Clinical Pharmacology·M J CushleyS T Holgate
Apr 1, 1972·Angiology·S Rodbard, S Kira
Oct 1, 1962·Der Tuberkulosearzt·W LUECKERATH

Related Concepts

Inhalation of Drugs
Intravenous Injections
Diastolic Blood Pressure
R-41,468
Forced Expiratory Flow Rates
Controlled Clinical Trials, Randomized
Vaporizers
Lung Diseases, Obstructive
Forced Expiratory Volume Function
Chronic Obstructive Airway Disease

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