Acute Respiratory Distress Syndrome: Bench-to-Bedside Approaches to Improve Drug Development

Clinical Pharmacology and Therapeutics
Musaddique HussainXimei Wu

Abstract

Despite 50 years of extensive research, no definite drug is currently available to treat acute respiratory distress syndrome (ARDS), and the supportive therapies remain the mainstay of treatment. To improve drug development for ARDS, researchers need to deeply analyze the "omics" approaches, reevaluate the suitable therapeutic targets, resolve the problems of inadequate animal modeling, develop the strategies to reduce the heterogeneity, and reconsider new therapeutic and analytical approaches for better designs of clinical trials.

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Methods Mentioned

BETA
ubiquitination
bronchoalveolar
lavage

Clinical Trials Mentioned

NCT02644798
NCT01757899
NCT01731795
NCT02895191
NCT03089957
NCT02819453
NCT02622724
NCT02326350
NCT01659307
NCT03042143

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