Abstract
In adult respiratory distress syndrome (ARDS), life-threatening hypoxemia may occur, dictating the need for differentiated ventilator strategies. Pronounced consolidation and/or atelectasis have been well documented in ARDS, but the contribution of regional perfusion to oxygenation has been poorly addressed. Evidence has accumulated that, in ARDS, regional perfusion is extremely variable and may affect oxygenation, independently from the amount of atelectatic-consolidated lung regions. Thus, the response in oxygenation to different ventilatory settings, both during controlled and assisted mechanical ventilation, should be interpreted with caution. In fact, gas exchange may be not determined solely by changes in aeration, but also redistribution of perfusion. Furthermore, regional perfusion can play an important role in worsening of lung injury due to increased transmural pressures. In addition, distribution of perfusion in lungs might affect the delivery of drugs through the pulmonary circulation, including antibiotics. In recent years, several techniques have been developed to determine pulmonary blood flow with increasing level of spatial resolution, allowing a better understanding of normal physiology and various pathophysio...Continue Reading
References
Jun 25, 1998·American Journal of Respiratory and Critical Care Medicine·A F BroccardJ J Marini
Feb 15, 2000·American Journal of Respiratory and Critical Care Medicine·J R HotchkissJ J Marini
Feb 25, 2000·Ultrasound in Medicine & Biology·A YuanF Y Lin
Apr 10, 2002·Critical Care Medicine·Serge BrimioulleDaniel P Schuster
May 14, 2005·Critical Care Medicine·Peter NeumannGöran Hedenstierna
Aug 11, 2006·Chest·Thomas LueckePaolo Pelosi
Apr 24, 2008·Critical Care Medicine·Marcelo Gama de AbreuThea Koch
Jan 20, 2009·American Journal of Respiratory and Critical Care Medicine·Peter M SpiethMarcelo Gama de Abreu
Oct 8, 2009·Anesthesiology·Henrik ReiniusFilip Fredén
Mar 25, 2010·Intensive Care Medicine·Felipe SaddyPatricia R M Rocco
Jan 26, 2011·Critical Care Medicine·Peter M SpiethMarcelo Gama de Abreu
Jan 29, 2011·Journal of Applied Physiology·Alysson R CarvalhoMarcelo Gama de Abreu
Feb 11, 2011·European Journal of Radiology·Christian GrieserTimm Denecke
Oct 1, 2011·Journal of Applied Physiology·João Batista BorgesMarcelo Amato
Nov 20, 2013·Current Opinion in Critical Care·Francesco CorradiPaolo Pelosi
Jan 11, 2014·Anesthesiology·Andreas GüldnerMarcelo Gama de Abreu
Aug 28, 2014·Critical Care Medicine·Nadja C CarvalhoMarcelo Gama de Abreu
Dec 17, 2014·Anesthesiology·Belaïd BouhemadIsabelle Rouquette
Jan 6, 2015·Acta Anaesthesiologica Scandinavica·H ReiniusF Lennmyr
Mar 26, 2015·BMC Anesthesiology·Torsten RichterThea Koch
Citations
Dec 19, 2015·BioMed Research International·András Lovas, Tamás Szakmány
Dec 22, 2016·Scientific Reports·K HorstF Hildebrand
Jan 22, 2019·Anesthesiology·Maurizio CeredaRahim R Rizi
Jul 7, 2019·Thorax·Charlotte OakleyMichael Wilson
Nov 5, 2017·Oncotarget·Zili ZhangHuiying Liu
May 30, 2020·PloS One·Thatyane de Castro QuirinoSabrina Epiphanio
Jul 26, 2016·Frontiers in Physiology·Isabela HenriquesPatricia R M Rocco
Apr 10, 2018·Clinical Hemorheology and Microcirculation·Johannes GramattéTorsten Richter
May 26, 2018·Physiological Measurement·Benjamin HentzeSteffen Leonhardt
Oct 30, 2020·Diagnostics·Saif AfatSebastian Gassenmaier
Jun 25, 2021·Physiological Measurement·Benjamin HentzeSteffen Leonhardt
Aug 29, 2021·Annals of Intensive Care·Huaiwu HeZhanqi Zhao