PMID: 11335048May 4, 2001Paper

Acute response of aortic nerve activity to free drop-induced microgravity in anesthetized rats

Neuroscience Letters
H MoritaN Fujiki

Abstract

To test the hypothesis that arterial baroreflex was stimulated during microgravity (microG), arterial pressure (AP), intrathoracic pressure (ITP), and aortic nerve activity (ANA) were measured in anesthetized rats during 4.5 s of microG produced by free drop. A smooth and immediate reduction in G occurred during free drop, microG being achieved 100 ms after the start of the drop. Acute microG elicited an immediate and striking, but transient, increase in ANA, with no significant change in the AP, but a significant decrease in the end-expiratory ITP. The calculated transmural pressure of the aorta increased by 6.9 mmHg 2 s after the start of the drop. The increase in ANA lasted 2 s, then ANA returned to the control level, despite the calculated end-expiratory transmural pressure still being high. These results suggest that microG conditions stimulate the aortic baroreceptor by increasing transmural pressure by reducing the ITP. However, this effect is only transient, probably due to the high-pass property of the baroreceptors.

Citations

May 12, 2007·Experimental Brain Research·Chikara AbeHironobu Morita
Feb 20, 2009·Experimental Brain Research·Yosuke NakamuraYasuaki Kawai
Jul 25, 2003·The Japanese Journal of Physiology·Hironobu MoritaKunihiko Tanaka
Mar 31, 2005·The Japanese Journal of Physiology·Taro Miyahara GotohHironobu Morita
Feb 7, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Taro Miyahara GotohHironobu Morita

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