Acute response of non-motor symptoms to subthalamic deep brain stimulation in Parkinson's disease

Parkinsonism & Related Disorders
Margherita FabbriJoaquim J Ferreira

Abstract

Subthalamic deep brain stimulation (STN-DBS) is an established treatment for the motor complications of Parkinson's disease (PD) and may have beneficial effects on non-motor symptoms (NMS). However, the acute effect of STN stimulation on NMS has only been explored in small PD cohorts with short post-surgical follow-up. To study NMS response to an acute stimulation challenge in an STN-DBS PD population with a medium/long-term post-surgical follow-up. 32 STN-DBS PD patients were tested twice (MED OFF/STIM OFF and MED OFF/STIM ON). MDS-UPDRS-III, blood pressure (BP) assessment, a visual analogue scale for pain and fatigue and State Trait Anxiety Scale score were evaluated during both stimulation conditions. NMS were assessed with MDS-UPDRS-I, Non-Motor Symptoms Scale, Geriatric Depression Scale and the Neuropsychiatric Inventory scale. Mean (SD) age was 62.5 (±13.3) years, mean disease duration 18.7 (±5.1) years, mean post-surgical follow-up 4.6 (±1.3) years, and the mean reduction of levodopa equivalent daily dose after surgery was 58.9% (±25.4%). Mean (SD) motor response to stimulation was 40% (15%). STN stimulation significantly improved anxiety (mean 18% ± 19%, P < 0.005) and fatigue (mean 25% ± 51%; P < 0.05), while pain, alt...Continue Reading

Citations

May 4, 2018·Expert Review of Neurotherapeutics·Kaylena A Ehgoetz Martens, James M Shine
May 12, 2020·Frontiers in Neuroanatomy·Aron EmmiRaffaele De Caro
May 7, 2019·Frontiers in Neuroscience·Lisa-Maria Schönfeld, Lars Wojtecki
Nov 28, 2019·Clinical Parkinsonism & Related Disorders·Yi-Cheng Tai, Chin-Hsien Lin

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