Acute Response of PGC-1α and IGF-1 Isoforms to Maximal Eccentric Exercise in Skeletal Muscle of Postmenopausal Women

Journal of Strength and Conditioning Research
Christina M Dieli-ConwrightE Todd Schroeder

Abstract

PGC-1α4, a novel isoform of the transcriptional coactivator PGC-1α, was recently postulated to modulate the expression of anabolic and catabolic genes and therefore regulate skeletal muscle hypertrophy. Resting levels of PGC-1α4 messenger RNA (mRNA) expression were found to increase in healthy adults after resistance training. However, the acute effect of resistance exercise (RE) on PGC-1α4 expression in populations prone to progressive muscle loss, such as postmenopausal women, has not been evaluated. Here, we investigated alterations in mRNA expression of PGC-1α4 and PGC-1α1, a regulator of muscle oxidative changes, in postmenopausal women after high-intensity eccentric RE and analyzed these findings with respect to changes in insulin-like growth factor (IGF)-1 and catabolic gene expression. Nine postmenopausal women (age, 57.9 ± 3.2 years) performed 10 sets of 10 maximal eccentric repetitions of single-leg extension with 20-second rest periods between sets. Muscle biopsies were obtained from the vastus lateralis of the exercised leg before and 4 hours after the RE bout with mRNA expression determined by quantitative real-time polymerase chain reaction. No significant changes in the mRNA expression of either PGC-1α isoform we...Continue Reading

References

Aug 1, 1996·Journal of Muscle Research and Cell Motility·S YangG Goldspink
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·E R Barton-DavisH L Sweeney
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Feb 4, 2003·The Journal of Physiology·Henriette PilegaardP Darrell Neufer
Apr 30, 2003·Journal of Applied Physiology·Niklas PsilanderHenriette Pilegaard
Jul 4, 2003·Medicine and Science in Sports and Exercise·Mette Aadahl, Torben Jørgensen
Aug 2, 2003·Journal of Anatomy·Maria HillG Goldspink
May 27, 2004·Physiological Genomics·Douglas J MahoneyMark A Tarnopolsky
Jan 13, 2005·American Journal of Physiology. Endocrinology and Metabolism·Jeong-su KimMarcas M Bamman
Aug 2, 2005·Cell Metabolism·Jiandie LinBruce M Spiegelman
Nov 4, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Vernon G CoffeyJohn A Hawley
Nov 30, 2005·Muscle & Nerve·Hans C DreyerRobert A Wiswell
Sep 15, 2006·Journal of Cellular Physiology·Victoria SiriettMridula Sharma
Jan 2, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ulrika RaueScott Trappe
Mar 26, 2008·Exercise and Sport Sciences Reviews·Martin J Gibala, Sean L McGee
Sep 11, 2008·Current Opinion in Genetics & Development·Zolt Arany
Aug 22, 2009·Journal of Applied Physiology·Christina M Dieli-ConwrightE Todd Schroeder
Feb 4, 2010·Journal of Strength and Conditioning Research·Nicole E JenskyE Todd Schroeder
Mar 10, 2010·Cardiovascular Research·David Alvarez-GuardiaManuel Vázquez-Carrera
Jul 30, 2011·Skeletal Muscle·Christopher S FryBlake B Rasmussen
Jun 1, 2013·The International Journal of Biochemistry & Cell Biology·H Q HanAlfred L Goldberg
Feb 13, 2014·European Journal of Applied Physiology·Rodrigo Fernandez-GonzaloJosé A de Paz
Feb 20, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Daniel I OgbornMark A Tarnopolsky

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