Acute restraint stress reduces protein kinase C gamma in the hippocampus of C57BL/6 but not DBA/2 mice

Neuroscience Letters
Robert K McNamara, Robert H Lenox

Abstract

Protein kinase C gamma (PKC gamma) is highly expressed in the rodent hippocampus and has been implicated in long-term alterations in synaptic efficacy. Acute stress has been shown to negatively affect hippocampal synaptic plasticity, and the present study examined the effect of acute stress on PKC gamma expression/subcellular distribution by quantitative western blotting in two inbred mouse strains (C57BL/6J versus DBA/2J) with established differences in hippocampal plasticity. It was found that both DBA/2J and C57BL/6J strains exhibited similar basal, stress-induced elevations, and recovery of serum corticosterone levels. Acute stress produced a significant reduction in both membrane and cytosolic PKC gamma expression in the hippocampus of C57BL/6J mice compared to no-stress controls, but did not alter either membrane or cytosolic PKC gamma expression in the hippocampus of DBA/2J mice compared to no-stress controls. These data provide direct evidence that PKC gamma is differentially regulated in the hippocampus of C57BL/6J and DBA/2J mice by acute stress. The role of stress-induced regulation of hippocampal PKC gamma expression in hippocampal synaptic plasticity is discussed.

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Citations

May 26, 2009·The International Journal of Neuroscience·Jess Nithianantharajah, Mark Murphy
Feb 7, 2019·Behavioural Pharmacology·Simona CabibStefano Puglisi Allegra
Feb 28, 2020·Brain Sciences·Simona CabibStefano Puglisi-Allegra
May 20, 2008·Neuroscience Letters·Danielle HaackAmelia Russo-Neustadt
Oct 27, 2009·Brain Research·Olga A TimofeevaEdward D Levin

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