Acute Retinal Necrosis: Presenting Characteristics and Clinical Outcomes in a Cohort of Polymerase Chain Reaction-Positive Patients

American Journal of Ophthalmology
Nicholas J ButlerJennifer E Thorne

Abstract

To identify determinants of adverse outcomes in acute retinal necrosis (ARN), presenting characteristics and incidence rates of vision loss and ocular complications in a cohort of polymerase chain reaction (PCR)-positive eyes were analyzed. Retrospective observational cohort study. Forty-one eyes of 36 patients with clinically diagnosed ARN, PCR-positive for herpes simplex virus or varicella zoster virus and evaluated between January 2002 and June 2013, were included. Main outcome measures included incidence rates of vision loss and retinal detachment (RD). Presenting visual acuity was generally poor (20/50 to >20/200 in 27%; 20/200 or worse in 56%). The incidence rate of ≤20/200 was 0.66/eye-year (EY), (95% confidence interval [CI], 0.32/EY to 1.22/EY); the rate of light perception or no light perception vision was 0.07/EY (95% CI, 0.02/EY to 0.16/EY). During follow-up, 59% of eyes developed at least 1 RD (rate = 0.40/EY, 95% CI, 0.19/EY to 0.58/EY). Eyes with retinitis involving ≥25% of the retina at presentation detached at nearly 12 times the rate, as compared to those with <25% retinal involvement (0.70/EY vs 0.06/EY; P = .001). Development of an RD was the greatest determinant of adverse visual outcomes, with 4% of eyes, ...Continue Reading

Citations

Mar 13, 2019·Clinical & Experimental Ophthalmology·Xia Ni WuOren Tomkins-Netzer
May 3, 2019·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Steven Charles Quan, Dimitra Skondra
Sep 7, 2018·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Sachin KedarJoseph R Berger
Sep 24, 2020·Ocular Immunology and Inflammation·Juliana WonsJustus G Garweg
May 30, 2019·BMJ Case Reports·Takaaki KobayashiJudy Streit
Apr 25, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Mora PaoloGuex-Crosier Yan
Jan 30, 2021·Asia-Pacific Journal of Ophthalmology·Anamika PatelSoumyava Basu
Apr 14, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Cristhian A UrzuaLourdes Arellanes-Garcia
May 28, 2021·Ophthalmic Surgery, Lasers & Imaging Retina·Lincoln T ShawDimitra Skondra
Aug 5, 2021·Ocular Immunology and Inflammation·Nihan Aksu-CeylanIlknur Tugal-Tutkun

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