PMID: 3754819Apr 1, 1986Paper

Acute reversible cataract induced by xylazine and by ketamine-xylazine anesthesia in rats and mice

Experimental Eye Research
L CalderoneM Shalev

Abstract

Combined administration of ketamine and xylazine is used increasingly for safe, effective anesthesia of small laboratory animals. We found that rats injected systemically with ketamine and xylazine at doses recommended for effective anesthesia developed acute reversible lens opacities. Mice given the same drug doses were similarly affected. Testing of each drug alone demonstrated that xylazine was the causative agent. The appearance of cataract was associated to varying degree with proptosis, suppression of the blink reflex, corneal surface drying, and mydriasis. All of these ocular effects, including cataract also could be induced locally by topical application of xylazine to one eye, with untreated contralateral eyes showing no drug effects. A possible cause of xylazine-induced transient lens opacification is trans-corneal water loss and alteration of aqueous humor composition due to corneal exposure. Additional action on aqueous humor formation and the lens itself may be due to the alpha-2-adrenoceptor nature of xylazine. Whatever the cause of cataract induction, the occurrence of this phenomenon during ketamine-xylazine anesthesia appears to be associated with marked changes in the physiological state of the eye. Therefore,...Continue Reading

References

Oct 1, 1967·Experimental Eye Research·M Weinstock, J D Scott
Jan 1, 1984·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·W ErhardtG Blümel
Jan 1, 1984·British Journal of Pharmacology·A LivingstonB Morris
Sep 1, 1981·Journal of Veterinary Pharmacology and Therapeutics·W H HsuP Lee

❮ Previous
Next ❯

Citations

Mar 1, 1992·Physiology & Behavior·K Kilander, H Williams
Aug 21, 2003·Brain Research. Brain Research Protocols·Maristela Oliveira PoletiniJanete A Anselmo-Franci
Feb 24, 2001·Journal of Psychoactive Drugs·K L Jansen
Dec 27, 2011·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Li-Fang HungEarl L Smith
Oct 3, 2007·Acta Ophthalmologica Scandinavica·Fengju ZhangPer G Söderberg
Apr 1, 2010·Acta Ophthalmologica·Konstantin GalichaninPer Söderberg
Feb 1, 2011·Current Eye Research·Maria A BermudezFrancisco Gonzalez
Jun 12, 2013·Veterinary Ophthalmology·Caroline J Zeiss
Sep 24, 2014·Experimental Eye Research·Brent A BellJoe G Hollyfield
Feb 16, 2013·Biomedical Optics Express·Jonathan J LiuJames G Fujimoto
Dec 24, 2014·Experimental Eye Research·Isha GuptaBalamurali K Ambati
Mar 7, 2006·Vision Research·Elena García de la CeraSusana Marcos
Sep 11, 2007·Vision Research·Ramkumar RamamirthamEarl L Smith
Jul 30, 2015·PloS One·Demelza KoehnMichael G Anderson
Apr 9, 2005·Methods in Enzymology·Russell N Van Gelder
May 17, 2002·The Journal of Physiology·Jennifer J Kang DerwentDavid R Pepperberg
Apr 30, 2009·Current Eye Research·Andres C VieiraFrancisco Gonzalez
Jul 1, 1997·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·C U MeteyerK Wesenberg
Aug 10, 2018·BioTechniques·Wataru IkedaAkiyoshi Uemura
Jun 1, 1997·Zentralblatt für Veterinärmedizin. Reihe A·N TomizawaS Hara
Mar 25, 2020·Laboratory animal research·Hun LeeKyoung Yul Seo
Mar 21, 2020·International Journal of Molecular Sciences·Mooud AmirkaveiAri Koskelainen
Nov 22, 2018·Analytical and Bioanalytical Chemistry·Anis Barmada, Scott A Shippy
Apr 2, 2020·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Talia AviramYinon Shapira
Jul 18, 2000·American Journal of Physiology. Cell Physiology·S Rao, A S Verkman
Sep 29, 2011·Visual Neuroscience·Walter F Heine, Christopher L Passaglia
Oct 8, 2020·Translational Vision Science & Technology·Anis Barmada, Scott A Shippy
May 28, 2019·Experimental Eye Research·Brent A BellIvy S Samuels
Mar 7, 2021·Experimental Eye Research·Michael PengWeiming Mao
Apr 22, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Melinda Wang, Fred Sanford Gorelick
Sep 4, 2010·Journal of Neuroscience Methods·Tatiana V Tkatchenko, Andrei V Tkatchenko

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.