Acute rhabdomyolysis and inflammation

Journal of Inherited Metabolic Disease
Yamina HamelPascale de Lonlay

Abstract

Rhabdomyolysis results from the rapid breakdown of skeletal muscle fibers, which leads to leakage of potentially toxic cellular content into the systemic circulation. Acquired causes by direct injury to the sarcolemma are most frequent. The inherited causes are: i) metabolic with failure of energy production, including mitochondrial fatty acid ß-oxidation defects, LPIN1 mutations, inborn errors of glycogenolysis and glycolysis, more rarely mitochondrial respiratory chain deficiency, purine defects and peroxysomal α-methyl-acyl-CoA-racemase defect (AMACR), ii) structural causes with muscle dystrophies and myopathies, iii) calcium pump disorder with RYR1 gene mutations, iv) inflammatory causes with myositis. Irrespective of the cause of rhabdomyolysis, the pathology follows a common pathway, either by the direct injury to sarcolemma by increased intracellular calcium concentration (acquired causes) or by the failure of energy production (inherited causes), which leads to fiber necrosis. Rhabdomyolysis are frequently precipitated by febrile illness or exercise. These conditions are associated with two events, elevated temperature and high circulating levels of pro-inflammatory mediators such as cytokines and chemokines. To illustr...Continue Reading

References

Feb 1, 1990·Annals of Neurology·P ToninS DiMauro
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·H KishiK Hori
Jul 1, 1988·Annals of Internal Medicine·C EastS M Grundy
Jul 1, 1987·The Journal of Clinical Investigation·K R Feingold, C Grunfeld
Apr 25, 1996·The New England Journal of Medicine·J KreuderF Lampert
Mar 29, 2000·Pediatric Neurology·B T Darras, N R Friedman
Apr 26, 2001·European Journal of Applied Physiology·K OstrowskiB K Pedersen
Aug 2, 2001·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·K PaillaF Blonde-Cynober
Feb 28, 2002·Annual Review of Immunology·Charles A Janeway, Ruslan Medzhitov
Mar 13, 2002·Critical Care Medicine·Elliott D CrouserDouglas R Pfeiffer
May 2, 2002·Proceedings of the National Academy of Sciences of the United States of America·Cecilia M DevlinIra Tabas
Dec 18, 2003·The Journal of Clinical Investigation·Stuart P WeisbergAnthony W Ferrante
Dec 18, 2003·The Journal of Clinical Investigation·Haiyan XuHong Chen
Jan 6, 2004·Annals of Neurology·Stefan KölkerGeorg F Hoffmann
Apr 13, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Ulrike Späte, P Christian Schulze
Apr 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Katie E PadfieldA Aria Tzika
Apr 21, 2005·The Journal of Biological Chemistry·Sven W SauerStefan Kölker
Sep 2, 2005·Nature·Steve E CalvanoUNKNOWN Inflamm and Host Response to Injury Large Scale Collab. Res. Program
Feb 10, 2006·The Journal of Biological Chemistry·Gil-Soo HanGeorge M Carman
Jun 24, 2006·Seminars in Fetal & Neonatal Medicine·Xiaoyang WangCarina Mallard
Dec 13, 2006·The Journal of Biological Chemistry·Jimmy DonkorKaren Reue
Apr 26, 2007·Orphanet Journal of Rare Diseases·Henry RosenbergKathryn Stowell
Sep 19, 2007·The Journal of Pharmacology and Experimental Therapeutics·Anni-Maija LindenEsa R Korpi
Apr 18, 2008·Pediatric Emergency Care·Raemma Paredes Luck, Sandi Verbin
Jun 25, 2008·Journal of Lipid Research·Kenneth R FeingoldCarl Grunfeld
Oct 23, 2008·American Journal of Physiology. Endocrinology and Metabolism·Biao LuKenneth R Feingold
Nov 19, 2008·Endocrine·Yongqing YangGongshe Yang
Mar 5, 2009·Journal of Clinical Neuromuscular Disease·Brian A van Adel, Mark A Tarnopolsky
Mar 14, 2009·Biochemical and Biophysical Research Communications·Yoshihiro TsuchiyaToshikatsu Okumura
May 16, 2009·Journal of Lipid Research·Kenneth R FeingoldCarl Grunfeld
Aug 20, 2009·Infectious Disorders Drug Targets·Víctor M VíctorMilagros Rocha
Sep 17, 2009·Cell Biochemistry and Function·Xiuping ChenYitao Wang
Sep 23, 2009·The Journal of Endocrinology·Mary C SugdenMark J Holness
Feb 25, 2010·American Journal of Physiology. Endocrinology and Metabolism·Madlyn I FrisardMatthew W Hulver
Mar 4, 2010·Epilepsia·Sandra El SabbaghIsabelle Desguerre
Mar 10, 2010·Cardiovascular Research·David Alvarez-GuardiaManuel Vázquez-Carrera

❮ Previous
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Citations

Feb 26, 2016·Meta Gene·Saied A JaradatJan Krayyem
Apr 12, 2016·Chemical Research in Toxicology·Theodore SakellaropoulosJane Pf Bai
Jul 3, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Cristiane CecattoMoacir Wajner
Oct 17, 2018·Pharmacogenomics·Paul J IsacksonGeorgirene D Vladutiu
Dec 3, 2016·BMJ Open Sport & Exercise Medicine·Renata S ScalcoNicol C Voermans
Oct 1, 2016·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Rita GaleirasAntonio Rodríguez
Jul 10, 2020·Journal of Dual Diagnosis·John R RichardsSamuel D Turnipseed
Jul 10, 2018·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Alexis ChenouardPierre Bourgoin
Oct 19, 2019·World Journal of Clinical Cases·Li-Na DingWen-Bin Shang
Feb 24, 2019·BMJ Case Reports·Richard PearseShumontha Dev
Mar 22, 2021·Molecular Genetics and Metabolism·Robin DagherBenoit J Gentil
Apr 16, 2017·Biochimica Et Biophysica Acta. Biomembranes·Peixiang Zhang, Karen Reue
Apr 13, 2021·Clinical Kidney Journal·Mirna Aleckovic-HalilovicAlexander Woywodt
Jul 2, 2021·Clinical & Translational Immunology·Abbe N VallejoJerry Vockley

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