Apr 19, 2013

Acute rifampicin-associated interstitial tubulopathy in a patient with pulmonary tuberculosis: a case report

Journal of Medical Case Reports
Silvia RosatiFabrizio Palmieri

Abstract

Rifampicin is one of the most effective antibiotics for treating tuberculosis, but it has been associated with adverse reactions, such as nephrotoxicity, sometimes resulting in acute renal failure with oligoanuria, and hepatotoxicity. Although deterioration of renal function, determined by acute tubulointerstitial nephritis and/or acute tubular necrosis, typically appears in patients receiving intermittent rifampicin therapy, some authors have also reported cases occurring during continuous rifampicin therapy. We describe the case of acute renal failure with polyuria occurring in a previously healthy 50-year-old Caucasian man undergoing continuous therapy with rifampicin for culture-confirmed pulmonary tuberculosis. The patient was admitted to the L. Spallanzani National Institute for Infectious Diseases, Rome, Italy, with a 1-month history of coughing, fever and weight loss. After 6 weeks of standard antituberculous treatment, progressive deterioration of his renal function was observed: creatinine levels rose from 38.9μmol/L to 318.2μmol/L and urine volume also progressively increased to reach a state of true polyuria (8 to 10L of urine per day). He was diagnosed with suspected acute rifampicin-induced renal failure. A renal ...Continue Reading

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References

Mentioned in this Paper

Urine
Kidney Function Tests
Creatinine
Kidney Failure
Tuberculosis
Antibiotic throat preparations
Coughing
Kidney Failure, Acute
Antifungal Antibiotics, Topical
Interstitial

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