Acute saline infusion decreases norepinephrine release in the anterior hypothalamic area

Hypertension
N PengJ M Wyss

Abstract

Ingestion of a high NaCl diet elevates arterial pressure in spontaneously hypertensive rats, at least in part, by reducing the release of norepinephrine in the anterior hypothalamic area. The mechanism by which dietary NaCl excess alters anterior hypothalamic area norepinephrine release is unknown. Plasma Na+ is slightly elevated after ingestion of a meal; therefore, in the present study we tested the hypothesis that a small increase in plasma Na+ could reduce the release of norepinephrine in the anterior hypothalamic area and elevate arterial pressure. Male spontaneously hypertensive rats were randomized to be fed a diet containing either 1% (basal) or 8% (high) NaCl at age 7 weeks and were maintained on the diets for 2 weeks. Age-matched normotensive Wistar-Kyoto rats received a basal NaCl diet only. All rats were instrumented with a push/pull cannula, and 5 days later, the baseline release of 3-methoxy-4-hydroxyphenyl glycol (the major metabolite of norepinephrine in brain) was measured in awake, freely moving rats. Rats were then challenged with an intravenous infusion (75 microL/min) of hypertonic (2.7%) saline for 20 minutes. In spontaneously hypertensive rats fed a basal NaCl diet, the hypertonic saline infusion elevated...Continue Reading

References

Jun 1, 1989·American Journal of Hypertension·S OparilY F Chen
Apr 1, 1988·The American Journal of the Medical Sciences·S OparilJ M Wyss
May 20, 1988·European Journal of Pharmacology·J DrewettG Trachte
Dec 1, 1985·Journal of the Royal Society of Medicine·G V GillJ Y Lawson
Oct 1, 1971·The Journal of Physiology·S M Hilton, K M Spyer
Nov 15, 1959·Acta Physiologica Scandinavica·B FOLKOWB OBERG

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Citations

Sep 12, 2000·Current Hypertension Reports·J M Wyss, S H Carlson
Sep 28, 2006·Clinical and Experimental Pharmacology & Physiology·Marcos A MayerAna M Puyó
Sep 15, 2005·Neuroscience Letters·Yuki TakayanagiTatsushi Onaka
May 12, 1998·The American Journal of Physiology·B S HuangF H Leenen
Jun 10, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Z FangJ M Wyss

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