Acute seizure suppression by transcranial direct current stimulation in rats

Annals of Clinical and Translational Neurology
Sameer C DhamneAlexander Rotenberg

Abstract

Cathodal transcranial direct current stimulation (tDCS) is a focal neuromodulation technique that suppresses cortical excitability by low-amplitude constant electrical current, and may have an antiepileptic effect. Yet, tDCS has not been tested in status epilepticus (SE). Furthermore, a combined tDCS and pharmacotherapy antiseizure approach is unexplored. We therefore examined in the rat pentylenetetrazol (PTZ) SE model whether cathodal tDCS (1) suppresses seizures, (2) augments lorazepam (LZP) efficacy, and (3) enhances GABAergic cortical inhibition. Experiment 1 aimed to identify an effective cathodal tDCS intensity. Rats received intraperitoneal PTZ followed by tDCS (sham, cathodal 1 mA, or cathodal 0.1 mA; for 20 min), and then a second PTZ challenge. In Experiment 2, two additional animal groups received a subtherapeutic LZP dose after PTZ, and then verum or sham tDCS. Clinical and electroencephalography (EEG) epileptic activity were compared between all groups. In Experiment 3, we measured GABA-mediated paired-pulse inhibition of the motor evoked potential by paired-pulse transcranial magnetic stimulation (ppTMS) in rats that received PTZ or saline, and either verum or sham tDCS. Cathodal 1 mA tDCS (1) reduced EEG spike b...Continue Reading

References

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Feb 24, 2015·Brain Stimulation·Daniel San-JuanFelipe Fregni

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Citations

Jul 4, 2016·Brain Stimulation·Marom BiksonAdam J Woods
Jun 18, 2016·Annals of Neurology·Yan SunAlexander Rotenberg
Jul 8, 2016·Expert Review of Neurotherapeutics·Markus Gschwind, Margitta Seeck
Oct 27, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mark P JacksonMarom Bikson
Mar 7, 2020·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Stephen VanHaerentsMouhsin M Shafi
Mar 7, 2020·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Ugur DamarAlexander Rotenberg
Jun 17, 2020·Annals of Neurology·Yan SunAlexander Rotenberg
Jul 18, 2018·Current Behavioral Neuroscience Reports·Carlos A Sánchez-LeónJavier Márquez-Ruiz
Nov 19, 2019·Frontiers in Integrative Neuroscience·Melissa TsuboyamaAlexander Rotenberg
Feb 24, 2017·Current Neurology and Neuroscience Reports·Mustafa Q HameedAlexander Rotenberg
Dec 19, 2020·Brain Stimulation·Daniel San-JuanAlexander Rotenberg
Mar 2, 2021·Molecular Diagnosis & Therapy·Rory J TinkerRobert McFarland
Jul 15, 2021·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Daniel San-Juan

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Software Mentioned

Neuroscore
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GraphPad
GraphPad Prism

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