Acute severe male hypo-testosteronemia affects central motor command in humans

Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology
Francesco FeliciLuigi Di Luigi

Abstract

To indirectly evaluate the effect of androgens on neuromuscular system in humans we analyzed if an induced short-term hypogonadal state (serum total testosterone-TT<2.3ng/ml) may affect central drive to skeletal muscle and/or muscle neuro-mechanical performance. We compared voluntary and electrically evoked muscle sEMG signals from biceps brachii in nine hypogonadal male volunteers (Hypo) and in ten healthy controls (Cont). Serum TT and dihydrotestosterone (DHT) were assayed. With respect to Hypo, Cont exhibited significantly higher median frequency content (MDF) at any angular velocity; normalized MDF [95.9% (SD=23.3) vs 73.8% (SD=9.3)]; muscle fiber conduction velocity (CV) from lowest to highest angular velocities; initial MDF at fatigue test [91.78Hz (SD=22.03) vs 70.94Hz (SD=11.06)] as well as was the normalized slope [-0.64 (SD=0.14 vs -0.5 (SD=0.11)]. In the non-fatigued state, Hypo showed a slower single twitches time to peak (TTP). In Cont, half relaxation time (HRT) decreased after fatigue while increased in Hypo (p<0.05 between groups). A significant correlation between both TT and dihydrotestosterone with MDF and CV was found during voluntary contractions only. A brief exposure to very low serum TT concentration in ...Continue Reading

References

Oct 8, 1999·Medical Engineering & Physics·A Burden, R Bartlett
Oct 6, 2000·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·H J HermensG Rau
Dec 18, 2001·Brain Research. Brain Research Reviews·K J JonesM Damaser
Apr 3, 2003·American Journal of Physiology. Endocrinology and Metabolism·Indrani Sinha-HikimShalender Bhasin
Dec 4, 2004·European Journal of Applied Physiology·Ilenia BazzucchiFrancesco Felici
Apr 24, 2007·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Ilenia BazzucchiFrancesco Felici
Nov 13, 2007·Trends in Endocrinology and Metabolism : TEM·Faisal Rahman, Helen C Christian
Sep 4, 2009·Medicine and Science in Sports and Exercise·Ilenia BazzucchiMassimo Sacchetti
Apr 14, 2011·Muscle & Nerve·Ilenia BazzucchiMassimo Sacchetti
Dec 20, 2013·The New England Journal of Medicine·Joel S FinkelsteinSherri-Ann M Burnett-Bowie
Oct 4, 2014·Journal of Applied Physiology·Dario FarinaRoger M Enoka

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Citations

Apr 15, 2017·Behavioural Brain Research·Marika BerchicciFrancesco Di Russo
Jul 20, 2018·Journal of Applied Physiology·Alessandro Del VecchioFrancesco Felici
Mar 24, 2017·Journal of Endocrinological Investigation·P Sgrò, L Di Luigi
Sep 23, 2020·Nutrients·Ilenia BazzucchiMassimo Sacchetti
Dec 22, 2019·Reviews in Endocrine & Metabolic Disorders·Giovanni CoronaFrancesco Lombardo

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