Acute sodium deficit triggers plasticity of the brain angiotensin type 1 receptors

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Geneviève CharronDidier Mouginot

Abstract

The brain renin-angiotensin system (bRAS) is involved in the control of hydromineral balance. However, little information is available on the functional regulation of the bRAS as a consequence of sodium deficit in the extracellular fluid compartments. We used a pharmacological model of acute Na+ depletion (furosemide injections) to investigate changes of a major component of the bRAS, the hypothalamic angiotensin type 1A (AT(1A)) receptors. Furosemide induced a rapid and long-lasting expression of the AT(1A) mRNA in the subfornical organ, the median preoptic nucleus (MnPO), and the parvocellular division of the paraventricular nucleus (pPVN). Na+ depletion increased the number of cells expressing AT(1A) mRNA in the pPVN, but not in the MnPO. The enhancement of AT(1A) mRNA expression was associated with an increase in AT(1) binding sites in all the regions studied. It is of interest that in the paraventricular nucleus, the majority of the neurons expressing AT(1A) mRNA also showed an increase in metabolic activity (Fos-related antigen immunoreactivity [FRA-ir]). By contrast, in the MnPO, we observe two distinct cell populations. Our data demonstrated that an acute Na+ deficit induced a functional regulation of the hypothalamic A...Continue Reading

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Citations

Apr 5, 2003·The International Journal of Biochemistry & Cell Biology·M J McKinleyS Y Chai
Mar 17, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Shun-Guang WeiRobert B Felder
Aug 30, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Eric LazartiguesRobin L Davisson
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Mar 22, 2018·Clinical and Experimental Hypertension : CHE·Barbara J MorganJohn M Dopp
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Aug 21, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alan Kim JohnsonBaojian Xue

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