Acute steroid responsive small-fiber sensory neuropathy: a new entity?

Journal of the Peripheral Nervous System : JPNS
Ron DabbyNathan Watemberg

Abstract

Small-fiber neuropathy is often idiopathic and commonly follows a chronic course. Treatment is often effective in treating the core symptom of pain, but it has no effect on the pathologic process. We describe four patients with acute small-fiber neuropathy who responded dramatically to steroid therapy. All patients had acute onset neuropathic pain, normal nerve conduction studies, and evidence of small-fiber dysfunction in quantitative sensory testing and skin biopsy. Symptoms were distal and symmetrical in three patients and generalized in one patient. In two cases, the neuropathy presented as an erythromelalgia-like syndrome. Marked clinical improvement occurred 1-2 weeks after oral prednisone therapy was initiated. Three patients remained symptom free, and one patient experienced recurrence of neuropathy after prednisone was tapered.

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Citations

Jan 26, 2016·Neuromuscular Disorders : NMD·Miguel Chuquilin, Upinder K Dhand
Feb 11, 2014·Disease-a-month : DM·Gary W Jay, Robert L Barkin
Nov 4, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Anne Louise Oaklander
May 7, 2013·Neurologic Clinics·Todd D Levine, David S Saperstein
Jun 22, 2006·Journal of the Peripheral Nervous System : JPNS·Einar-P Wilder-Smith
Jun 15, 2007·Journal of the Peripheral Nervous System : JPNS·Ron DabbyMenachem Sadeh
Mar 21, 2012·Muscle & Nerve·Antonino Uncini, Nobuhiro Yuki
Feb 14, 2016·Muscle & Nerve·Amanda Cy Chan, Einar P Wilder-Smith
Jul 31, 2013·Pain·Anne Louise OaklanderMax M Klein
Jul 2, 2017·Muscle & Nerve·Nobuhiro YukiEinar Wilder-Smith
Jan 24, 2007·Anesthesia and Analgesia·Joshua PaticoffAnne Louise Oaklander
May 30, 2012·Nature Reviews. Neurology·Janneke G HoeijmakersStephen G Waxman
May 10, 2019·BMJ : British Medical Journal·Kelly Graham Gwathmey, Kathleen T Pearson
Oct 13, 2016·Journal of Neurology·Magdalena LangAnne Louise Oaklander
Apr 11, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Natalia Y BasantsovaYehuda Shoenfeld
Feb 7, 2018·Therapeutic Advances in Neurological Disorders·Xiaolei LiuAnne Louise Oaklander
Jul 3, 2020·Journal of Neurology·Taylor Pindi SalaCristina Belizna
Jul 30, 2020·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Nicole FaignartEliane Roulet Perez
Aug 11, 2021·Muscle & Nerve·Franco GemignaniGiovanni Pavesi

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