Acute Stress Decreases but Chronic Stress Increases Myocardial Sensitivity to Ischemic Injury in Rodents

Frontiers in Psychiatry
Eric D EisenmannPhillip R Zoladz


Cardiovascular disease (CVD) is the largest cause of mortality worldwide, and stress is a significant contributor to the development of CVD. The relationship between acute and chronic stress and CVD is well evidenced. Acute stress can lead to arrhythmias and ischemic injury. However, recent evidence in rodent models suggests that acute stress can decrease sensitivity to myocardial ischemia-reperfusion injury (IRI). Conversely, chronic stress is arrhythmogenic and increases sensitivity to myocardial IRI. Few studies have examined the impact of validated animal models of stress-related psychological disorders on the ischemic heart. This review examines the work that has been completed using rat models to study the effects of stress on myocardial sensitivity to ischemic injury. Utilization of animal models of stress-related psychological disorders is critical in the prevention and treatment of cardiovascular disorders in patients experiencing stress-related psychiatric conditions.


Feb 1, 1979·The American Journal of Cardiology·B Lown
Jul 1, 1979·Proceedings of the Society for Experimental Biology and Medicine·B LiangB Lown
Sep 1, 1978·Annals of Internal Medicine·G L Engel
May 26, 1977·The American Journal of Cardiology·B LownS H Rabinowitz
Aug 1, 1992·Cardiovascular Research·M P Pye, S M Cobbe
Jan 1, 1992·Neuroscience and Biobehavioral Reviews·E O JohnsonP W Gold
Jul 1, 1991·Psychosomatic Medicine·J K Kiecolt-GlaserR Glaser
May 25, 1991·Proceedings of the National Academy of Sciences of the United States of America·R H PurdyS M Paul
Dec 8, 1991·The New England Journal of Medicine·A C YeungA P Selwyn
Apr 1, 1987·Journal of Molecular and Cellular Cardiology·M J CurtisM J Walker
Apr 21, 1988·The New England Journal of Medicine·A RozanskiD S Berman
Jan 1, 1987·Circulation·R L VerrierB Lown
Jun 1, 1985·The Australian and New Zealand Journal of Psychiatry·C TennantD Byrne
Nov 1, 1985·The Journal of Clinical Investigation·E Braunwald, R A Kloner
May 1, 1971·Annals of Internal Medicine·G L Engel
Jul 1, 1969·Journal of Comparative and Physiological Psychology·H L RatcliffeK Chacko
Nov 3, 1984·Lancet·J E DeanfieldA P Selwyn
Jan 1, 1984·Annual Review of Physiology·R L Verrier, B Lown
May 1, 1995·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·H BleuelW Rebel
Oct 1, 1994·The Journal of Clinical Investigation·R A GottliebR L Engler
Jul 1, 1994·Clinical Cardiology·F Z Meerson
Jan 27, 1994·The New England Journal of Medicine·D S RosenbaumR J Cohen
May 1, 1996·Cardiology Clinics·D S KrantzJ S Gottdiener
Sep 15, 1996·The American Journal of Cardiology·J C BarefootR B Williams
Aug 1, 1997·Psychoneuroendocrinology·I LiberzonE A Young

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.


Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.


Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

Current Opinion in Endocrinology, Diabetes, and Obesity
Joshua J Joseph, Sherita Hill Golden
© 2022 Meta ULC. All rights reserved