PMID: 9443660Jan 27, 1998Paper

Acute stress enhances anxiolytic-like drug responses of mice tested in a black and white test box

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
C Sánchez

Abstract

Drug-induced facilitation of exploration of a two-compartment black and white test box was studied in mice applying different stressors before test. Tail suspension suppressed exploration of both compartments and enhanced diazepam- or eltoprazine-induced increase of exploration of the white compartment. (-)-Penbutolol reversed the effects of eltoprazine suggesting involvement of 5-HT(1A/1B) receptors. Buspirone had weak effects both under standard conditions, and after tail suspension. Ritanserin suppressed exploratory behavior, and this effect was potentiated by tail suspension. In conclusion, application of acute tail suspension stress immediately before test in the black and white box enhanced the sensitivity to drugs. In contrast to this, forced swimming suppressed general behavioral activity, but in this case diazepam facilitated the behavior in both compartments. Foot shocks immediately before test reduced activity in the black compartment and did not affect the behavior in the white compartment. Thus different acute stressors modified behavior in the black and white box differently. Chronic stress (crowded housing) produced an anxiolytic-like response.

References

Oct 1, 1992·Pharmacology, Biochemistry, and Behavior·C López-RubalcavaA Fernández-Guasti
Nov 3, 1992·European Journal of Pharmacology·S Hjorth
Jan 1, 1990·Drug Metabolism and Drug Interactions·B OlivierD Rasmussen
Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·E S Onaivi, B R Martin
Mar 1, 1989·Pharmacology, Biochemistry, and Behavior·B CostallD M Tomkins
Aug 1, 1980·Pharmacology, Biochemistry, and Behavior·J Crawley, F K Goodwin
Jan 1, 1996·Pharmacology, Biochemistry, and Behavior·F G GraeffP O Mora

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Citations

May 29, 2012·Behavioural Brain Research·Golan Karvat, Tali Kimchi
Aug 14, 2003·Fundamental & Clinical Pharmacology·Caroline E RenardMichel Bourin
Dec 22, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Eszter Majercsik, József Haller
Apr 29, 2011·Behavioral and Brain Functions : BBF·Tatyana StrekalovaHarry Mw Steinbusch
Apr 3, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Anna MorozovaVladimir Chekhonin
Dec 7, 2013·Stress : the International Journal on the Biology of Stress·João Costa-NunesTatyana Strekalova
Feb 26, 2015·Brain, Behavior, and Immunity·Tatyana StrekalovaDaniel C Anthony
May 14, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Bruce C KennedyPhu V Tran
Apr 30, 2020·Animals : an Open Access Journal From MDPI·Chikako ShimizuToshitaka Nabeshima

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