Acute stroke treatment using the Penumbra endovascular mechanical thrombolysis device: a single-centre experience.

La Radiologia medica
R GandiniG Simonetti

Abstract

Ischaemic stroke due to occlusion of large cerebral vessels has a poor prognosis. The clinical outcome is related to efficacy and timing of recanalisation of the occluded arteries. We report our experience with a thrombus aspiration device (Penumbra), and focus on pre- and postprocedural management. We retrospectively reviewed 18 consecutive patients with acute ischaemic stroke due to the occlusion of large cerebral vessels who were treated with mechanical thrombolysis at our centre between September 2009 and July 2010. Preprocedural symptoms were quantified using the National Institutes of Health Stroke Scale (NIHSS). Mechanical thrombolysis was performed with the Penumbra system. Intravenous thrombolysis was done only if <3 h had elapsed since symptom onset. Associated vessel stenoses were treated with stenting. All patients underwent neurological examination and postprocedural magnetic resonance angiography (MRA) at 3 and 6 months. Mechanical thrombolysis using the Penumbra system was performed in all cases. A total of 83% of treated vessels had a value of 2/3 according to the Thrombolysis in Cerebral Infarction (TICI) scale. In seven patients (39%) intravenous thrombolysis was unsuccessful, and salvage mechanical thrombolys...Continue Reading

References

Dec 1, 1988·Stroke; a Journal of Cerebral Circulation·R Bonita, R Beaglehole
Dec 14, 1995·The New England Journal of Medicine·UNKNOWN National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
May 7, 1999·Stroke; a Journal of Cerebral Circulation·K W MuirK R Lees
Aug 6, 1999·Stroke; a Journal of Cerebral Circulation·S E KasnerA R Localio
Jul 10, 2002·Stroke; a Journal of Cerebral Circulation·Mario Di NapoliUNKNOWN Villa Pini Stroke Data Bank Investigators
Mar 8, 2003·Stroke; a Journal of Cerebral Circulation·Lise A LabicheAndrei V Alexandrov
Mar 29, 2003·Stroke; a Journal of Cerebral Circulation·Peter U HeuschmannUNKNOWN Competence Net Stroke
Nov 19, 2004·The New England Journal of Medicine·Andrei V AlexandrovUNKNOWN CLOTBUST Investigators
Jun 18, 2005·Stroke; a Journal of Cerebral Circulation·Wade S SmithUNKNOWN MERCI Trial Investigators
Dec 2, 2006·Stroke; a Journal of Cerebral Circulation·Maher SaqqurUNKNOWN CLOTBUST Investigators
Sep 22, 2007·AJNR. American Journal of Neuroradiology·T Tomsick
May 24, 2008·AJNR. American Journal of Neuroradiology·A BoseUNKNOWN Penumbra Phase 1 Stroke Trial Investigators
Aug 8, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·I Q GrunwaldC Roth
Dec 19, 2009·AJNR. American Journal of Neuroradiology·Z KulcsárD A Rüfenacht
Aug 14, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Giuseppe LippiMassimo Franchini

❮ Previous
Next ❯

Citations

Apr 13, 2013·AJNR. American Journal of Neuroradiology·J E FugateD F Kallmes
Jun 6, 2015·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Roberto GandiniEnrico Pampana

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.