Acute 'strokenomics': efficacy and economic analyses of alteplase for acute ischemic stroke

Expert Review of Pharmacoeconomics & Outcomes Research
Terence J Quinn, Jesse Dawson

Abstract

Cerebrovascular disease is the leading cause of adult disability in Western countries and, as such, is associated with a considerable and increasing economic burden. Prevention of disability is preferable to a costly and prolonged period of rehabilitation; however, in this regard, we have only a limited number of acute treatments. Treatment of ischemic stroke with the tissue plasminogen activator alteplase has a considerable and compelling evidence base confirming its clinical efficacy. Good-quality trial data are complemented by years of 'real-life' clinical experience. There is limited pharmacoeconomic literature describing the use of alteplase in ischemic stroke, and published data are consistent and broadly supportive of its use in select patient populations. Delivery of stroke and other medical care can differ across countries; however, models based on American, Canadian and European data suggest that following initial monetary investment, net healthcare-associated costs for tissue plasminogen activator-treated patients are less than for untreated contemporaries. Potential savings are driven by reduced disability and associated long-term care costs. At present, robust economic data are only available for the period of 1-ye...Continue Reading

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Citations

Jul 1, 2012·Journal of Comparative Effectiveness Research·Terence J Quinn, Jesse Dawson
Jan 28, 2012·Expert Review of Pharmacoeconomics & Outcomes Research·P Fearon, T J Quinn
Apr 12, 2011·Expert Review of Pharmacoeconomics & Outcomes Research·Terence J Quinn
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May 26, 2012·Stroke; a Journal of Cerebral Circulation·Hans KruegerMichael D Hill

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