PMID: 7938754Jan 1, 1994Paper

Acute, subacute, and chronic x-ray effects on glomerular hemodynamics in rats

Renal Failure
V de P TeixeiraN Schor

Abstract

In order to evaluate the effects of x-rays on glomerular hemodynamics, surgically exposed left kidneys of Munich-Wistar rats were irradiated with 15 Gy in a single dose. The animals were studied 45 min (acute group, n = 8), 14 days (subacute group, n = 7), and 60 days (chronic group, n = 7) after irradiation and compared with their respective controls. A decrease in total glomerular filtration (55%) and renal plasma flow (40%) rates with marked elevation of total renal vascular resistance (180%), p < 0.05, occurred within 45 min. Significant changes also occurred in the microcirculation; i.e., single-nephron glomerular filtration (SNGFR), glomerular plasma flow (QA), and glomerular capillary hydraulic pressure (PGC) declined by 35%, 40%, and 12%, respectively, due to an increase in total arteriolar resistance (90%), p < 0.05. Within 14 days, SNGFR was similar to control in spite of a moderate elevation of afferent arteriolar resistance (26%) and reduction in PGC (11%), p < 0.05, and QA (20%). Kf was significantly elevated (46%), p < 0.05. The chronic group presented a response pattern similar to that of the acute group, although less severe. Histopathological changes were not relevant and were restricted to tubules. The present...Continue Reading

References

Jan 1, 1976·The American Journal of Medicine·W F KeaneF L Shapiro
Sep 1, 1992·Kidney International·M A BoimN Schor
Oct 1, 1991·Kidney International·O F Dos SantosN Schor
Oct 1, 1989·Kidney International·J R LugonN Schor
Nov 1, 1972·The American Journal of Physiology·W M DeenB M Brenner
Jun 1, 1973·The Journal of Clinical Investigation·W M DeenB M Brenner
May 1, 1953·The American Journal of Physiology·M L MENDELSOHN, E CACERES
Feb 1, 1957·The American Journal of Physiology·L H SMITH, W R BOSS
May 1, 1945·The Journal of Clinical Investigation·H W SmithM Graber

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Citations

Apr 24, 2016·American Journal of Physiology. Heart and Circulatory Physiology·John D ImigEric P Cohen

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