Acute, subacute toxicity and genotoxic effect of Bio-Quinone Q10 in mice and rats

Regulatory Toxicology and Pharmacology : RTP
Xin FuJorgen Dam

Abstract

In the present study, the acute, subacute and genetic toxicity of Coenzyme Q10 (CoQ10) in the form of Bio-Quinone (Pharma Nord, Denmark) was assessed. LD(50) of CoQ10 by oral treatment was greater than 20g/kg body weight in both female and male mice. Genotoxicity was assessed in mice by Ames test in Salmonella typhimurium strains TA97, TA98, TA100 and TA102, by bone marrow micronucleus test and sperm abnormality. Thirty-day subacute toxicity was conducted with oral daily dose at 0, 0.56, 1.13 and 2.25g/kg body weight in rats. No significant changes in body weight, food intake, behavior, mortality, hematology, blood biochemistry, vital organ weight, sperm abnormality, mutagenicity and micronucleus formation were observed and no clinical signs or adverse effects were detected by administration of CoQ10. These results support the safety of CoQ10 for oral consumption.

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Citations

Oct 4, 2011·Mutation Research·Constance Schmelzer, Frank Döring
May 23, 2009·Regulatory Toxicology and Pharmacology : RTP·Amit Kumar MehtaBhanu Pratap Singh
Jul 31, 2013·Regulatory Toxicology and Pharmacology : RTP·Masahiko NakanoBarry Lynch
Feb 26, 2013·Neurotoxicology·Carla da Silva MachadoLusânia Maria Greggi Antunes
Jul 17, 2010·International Journal of Toxicology·Xiao-bo HuMing-yong Xie
Aug 5, 2009·The Journal of Toxicological Sciences·Noriko YamaguchiKoichi Wakigawa
May 7, 2019·Journal of Toxicology·Gajanan DeshmukhPrasad Shivarudraiah
Jul 2, 2021·Toxicology Reports·Natalia Ehrenhaus MasottaValeria P Tripodi

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