Acute suppression, but not chronic genetic deficiency, of c-fos gene expression impairs long-term memory in aversive taste learning.

Proceedings of the National Academy of Sciences of the United States of America
Y YasoshimaT Yamamoto

Abstract

Several lines of evidence have indicated that the establishment of long-term memory requires protein synthesis, including the synthesis of immediate-early gene products. Although the anatomical expression patterns of the c-fos gene, a transcription factor-encoding immediate-early gene, in conditioned taste aversion (CTA) are well documented, the functional roles of c-fos gene expression and Fos-mediated transcription remain to be clarified. Using the antisense oligodeoxynucleotide (AS-ODN) method in rats and gene-targeting knockout techniques in mice (c-fos(-/-) mice), we examined the roles of c-fos gene expression in the acquisition, retrieval, and retention of CTA. Preconditioning microinfusion of AS-ODN directed against c-fos mRNA (c-fos AS-ODN) into the parabrachial nucleus (PBN) impaired the acquisition, whereas infusion of control ODNs consisting of a randomized or inverted base order had no effect. Microinfusion of c-fos AS-ODN into either the amygdala or insular cortex did not impair the acquisition, whereas it attenuated the retention. Retrieval and subsequent retention of an acquired CTA were not disrupted by c-fos AS-ODN infusion into the PBN or amygdala. Microinfusion of another AS-ODN directed against zif268 (egr-1...Continue Reading

References

Jan 1, 1992·Brain Research. Molecular Brain Research·K J Mack, P A Mack
Dec 24, 1992·Nature·Z Q WangE F Wagner
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A M GraybielH A Robertson
Oct 1, 1994·Cellular and Molecular Neurobiology·M DragunowP Lawlor
Mar 1, 1995·Neuroscience Research·T YamamotoN Sakai
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·C H BaileyE R Kandel
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·J F Guzowski, J L McGaugh
Jan 15, 2000·Science·J L McGaugh
Nov 9, 2000·Genes & Development·A FleischmannE F Wagner
Jan 16, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jue HeToshitaka Nabeshima
Apr 27, 2002·Nature·Subhabrata SanyalMani Ramaswami
Nov 26, 2002·Brain Research·Hamid KarimnamaziJoseph B Travers
Jun 24, 2003·Neuron·María Eugenia Pedreira, Héctor Maldonado
Feb 20, 2004·Journal of Neurophysiology·Ken'ichi TokitaTakashi Yamamoto
Feb 21, 2004·Nature Reviews. Neuroscience·Federico Bermúdez-Rattoni
Mar 31, 2004·Cellular and Molecular Neurobiology·Federico Bermúdez-RattoniMaría Isabel Miranda
Nov 3, 2004·Brain Research. Molecular Brain Research·Peter GassRolf Sprengel
Aug 27, 2005·Neurobiology of Learning and Memory·Renee A CountrymanPaul J Colombo
Jul 22, 1955·Science

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Citations

Mar 30, 2013·The Journal of Physiological Sciences : JPS·Ema SuzukiTakenori Miyamoto
Feb 12, 2013·Brain Research Bulletin·Jan BenesJaromir Myslivecek
Sep 9, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dong Hyun KimJong Hoon Ryu
Feb 29, 2008·Proceedings of the National Academy of Sciences of the United States of America·Riccardo Accolla, Alan Carleton
Feb 21, 2009·Proceedings of the National Academy of Sciences of the United States of America·Susy M KimMani Ramaswami
May 8, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lorena Saavedra-RodríguezSandra Peña de Ortiz
Feb 9, 2007·Archives of Histology and Cytology·Takashi Yamamoto
Sep 23, 2014·Brain Research Bulletin·Esperanza QuinteroJuan Carlos López
Aug 19, 2009·Annals of the New York Academy of Sciences·Takashi YamamotoKeiko Abe
Jul 31, 2013·The European Journal of Neuroscience·Neville-Andrew NiessenThierry D Charlier
Sep 15, 2014·Brain Research Bulletin·Dong Hyun KimJong Hoon Ryu
Nov 29, 2011·Physiology & Behavior·Siva K PanguluriRobert F Lundy
Mar 1, 2012·Brain Research Bulletin·Jan BenesJaromir Myslivecek
Oct 11, 2016·NPJ Science of Learning·David LevitanKobi Rosenblum
May 12, 2015·PloS One·Masahito MatsumotoMasaharu Noda
Oct 28, 2016·Cell Death & Disease·Jayasha ShandilyaKathryn F Medler
Jan 14, 2018·Journal of Molecular Histology·Honghua SongYoujia Wu
Nov 23, 2017·Frontiers in Molecular Neuroscience·Adonis Yiannakas, Kobi Rosenblum
Jan 1, 2013·Neuroscience Journal·Siva K PanguluriRobert F Lundy
Jun 15, 2020·Behavioural Brain Research·Roberto A Prado-AlcaláAndrea C Medina
Apr 3, 2021·Neurobiology of Learning and Memory·C X Ruiz-LópezR A Prado-Alcalá

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