PMID: 3771150Oct 1, 1986Paper

Acute systemic and renal hemodynamic effects of meglumine/sodium diatrizoate 76% and iopamidol in euvolemic and dehydrated dogs

Investigative Radiology
R W KatzbergB A McKenna

Abstract

We examined the acute systemic and renal hemodynamic effects of intravenous meglumine/sodium diatrizoate-76% and iopamidol in euvolemic and dehydrated dogs. The physiologic responses were compared with acute changes in the level of an endogenous heparin-like material (EHM). One of eight dehydrated dogs receiving diatrizoate (2 ml/kg) had an immediate vomiting reflex associated with a very significant decline in all measured renal hemodynamic parameters; none of eight dehydrated dogs receiving iopamidol experienced a similar reaction. EHM levels did not correspond to the magnitude of the physiologic responses following either iopamidol or diatrizoate. Significant differences between iopamidol and diatrizoate were noted when comparing the magnitude of the decrease in systemic pressure (- delta 3.8 +/- 3.02, iopamidol, n = 8; vs. - delta 19.4 +/- 7.3 mm Hg, diatrizoate, n = 8; P less than .03), increased renal plasma flow (+ delta 6.2 +/- 4.9, iopamidol, n = 8; vs. + delta 33.7 +/- 8.0 ml/min, diatrizoate, n = 8; P less than .05), and decreased filtration fraction (- delta 0.09 +/- 0.01, iopamidol, n = 8; vs. - delta 0.14 +/- 0.02, diatrizoate, n = 8; P less than .03). There was no significant difference in the decrease in glomeru...Continue Reading

Citations

Sep 5, 1998·The Surgical Clinics of North America·M R BackJ M Seeger
Jun 1, 1993·Annals of Surgery·J M SeegerI F Hawkins
Oct 21, 2003·Investigative Radiology·Werner Krause, Thomas Gilles
Jan 1, 1994·Fundamental & Clinical Pharmacology·J M IdéeB Bonnemain
Oct 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M R RudnickS Goldfarb
Jan 1, 1989·Scandinavian Journal of Urology and Nephrology·B Spångberg-ViklundP Nyberg
Nov 5, 1999·Investigative Radiology·S N HeymanM Brezis
Apr 1, 1991·Catheterization and Cardiovascular Diagnosis·W H Matthai, J W Hirshfeld

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