Acute systemic complications in the preterm fetus after asphyxia: role of cardiovascular and blood flow responses

Clinical and Experimental Pharmacology & Physiology
L BennetA J Gunn

Abstract

1. Poor perfusion of the kidneys and gut, and associated functional impairment, are major problems in the first days of life in very preterm infants. These complications can be associated with a substantial mortality and further problems such as reduced kidney growth and chronic renal problems in later childhood. 2. There is very little information, and consequently considerable debate, about how or even whether to improve perfusion of the vital organs of this most vulnerable group of babies. Current treatments simply do not consistently improve babies' perfusion generally or kidney and gut perfusion and function in particular. 3. In this review we critically examine clinical and experimental evidence that suggests that exposure to low oxygen levels before and during birth may be a significant contributor to impaired systemic perfusion, and highlight areas requiring further research. 4. This knowledge is essential to develop and refine ways of improving perfusion of the kidneys and other vital organs in premature babies.

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Citations

Mar 22, 2008·Intensive Care Medicine·Chloë JoyntPo-Yin Cheung
Jul 12, 2012·Clinical and Experimental Pharmacology & Physiology·Laura BennetAlistair J Gunn
Aug 20, 2009·Annals of Tropical Paediatrics·T DukeB Frey
Jan 24, 2015·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Hossein S MirheydarRoger L Sur
Dec 2, 2017·Developmental Medicine and Child Neurology·Robert GalinskyAlistair J Gunn
Mar 16, 2018·Scientific Reports·Carlos Menendez-CastroAndrea Hartner
Dec 26, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lindsea C BoothLaura Bennet
May 24, 2011·Experimental Physiology·Lindsea C BoothLaura Bennet
May 4, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lindsea C BoothLaura Bennet

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