Acute temporal regulation of vascular endothelial growth/permeability factor expression and endothelial morphology in the baboon endometrium by ovarian steroids

The Journal of Clinical Endocrinology and Metabolism
E D AlbrechtG J Pepe

Abstract

We recently showed that endometrial vascular endothelial growth/permeability factor (VEG/PF) mRNA expression was decreased by ovariectomy of baboons and restored by chronic administration of estrogen. However, it remains to be determined whether this effect of estrogen reflects genomic up-regulation of VEG/PF and leads to an increase in microvascular permeability, an early physiological event in angiogenesis. Therefore, we determined the temporal expression of VEG/PF mRNA in glandular epithelial and stromal cells isolated by laser capture microdissection from and width of microvascular paracellular clefts that regulate vessel permeability in the endometrium of ovariectomized baboons after acute estradiol and/or progesterone administration. Endometrial VEG/PF mRNA levels were increased in five of five animals within 2 h of estradiol administration and remained elevated at 4 and 6 h. The net increase in glandular epithelial (7.31 +/- 2.72 attomol/fmol 18S ribosomal rRNA) and stromal (3.13 +/- 0.36) cell VEG/PF mRNA levels after estradiol administration was over 8-fold (P < 0.05) and 2.6-fold (P < 0.01) greater, respectively, than after vehicle (0.90 +/- 0.30, glands and 1.20 +/- 0.33, stroma). In contrast, endometrial VEG/PF mRNA...Continue Reading

References

Nov 1, 1991·Journal of Cellular Biochemistry·N FerraraD W Leung
Jan 1, 1991·Progress in Biophysics and Molecular Biology·G Clough
Jul 1, 1988·The Journal of Clinical Endocrinology and Metabolism·E GarciaM Perrot-Applanat
Aug 1, 1985·DNA·R M TorczynskiA P Bollon
Feb 1, 1997·Endocrine Reviews·N Ferrara, T Davis-Smyth
Feb 23, 1999·Human Reproduction Update·S K Smith
Feb 29, 2000·American Journal of Obstetrics and Gynecology·E D AlbrechtG J Pepe
Sep 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·M D MuellerR N Taylor
Oct 19, 2000·Environmental Health Perspectives·S M HyderG M Stancel
Feb 28, 2001·Reproduction : the Official Journal of the Society for the Study of Fertility·C E Gargett, P A Rogers
Apr 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Nihar R Nayak, Robert M Brenner

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Citations

Oct 8, 2005·Angiogenesis·Oliver P Milling Smith, Hilary O D Critchley
Oct 8, 2005·Angiogenesis·Jane E Girling, Peter A W Rogers
Nov 29, 2007·Journal of Assisted Reproduction and Genetics·Gérard ChaouatNathalie Ledée
Oct 8, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Shenna Y LangenbachGregory I Snell
Feb 8, 2008·Reproduction, Fertility, and Development·Gracy X RosarioGeetanjali Sachdeva
Feb 4, 2009·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Gaia GoteriAndrea Ciavattini
Jul 27, 2011·Therapeutic Advances in Medical Oncology·Shari B GoldfarbMaura N Dickler
Dec 18, 2008·Reproductive Biology and Endocrinology : RB&E·Chishimba N MowaGuichuan Hou
Mar 21, 2013·Journal of Translational Medicine·Leo BockeriaAmit N Patel
Oct 31, 2009·The International Journal of Developmental Biology·Eugene D Albrecht, Gerald J Pepe
Jun 10, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Lisa M WalterJane E Girling
Dec 8, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·Kevin Y Lee, Francesco J DeMayo
Jun 1, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·Lisa M WalterJane E Girling
Dec 17, 2009·Women's Health·Shari B GoldfarbMaura N Dickler
May 22, 2007·Hematology/oncology Clinics of North America·Tiffany A TrainaMaura Dickler
Aug 8, 2008·Basic & Clinical Pharmacology & Toxicology·Mehdi NematbakhshShahram Rafieian
May 19, 2011·Journal of Pineal Research·José C DayoubGermaine Escames
Feb 9, 2010·Molecular Reproduction and Development·Thomas W BonaguraEugene D Albrecht
Dec 31, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Pelin Costur BiyiksizBirol Vural
Apr 25, 2017·Journal of Cellular Biochemistry·Mostafa Peyvandi KarizbodaghHamed Mirzaei
Nov 2, 2018·Molecular Reproduction and Development·Paula TríbuloPeter J Hansen
Aug 22, 2008·Immunological Investigations·Caroline DunkRebecca Lee Jones
Apr 21, 2016·The Cochrane Database of Systematic Reviews·Devashana GuptaVicki Nisenblat
Sep 15, 2005·Endocrine Reviews·Henry N JabbourHilary O D Critchley
Oct 11, 2017·Molecular Medicine Reports·Maria I ZervouGeorge N Goulielmos

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