PMID: 9170015Apr 1, 1997Paper

Acute therapy for hyperkalemia with the combined regimen of bicarbonate and beta(2)-adrenergic agonist (salbutamol) in chronic renal failure patients

Journal of Korean Medical Science
H J Kim

Abstract

This study was aimed to evaluate the efficacy of combination therapy of bicarbonate and salbutamol for hyperkalemia in 9 hemodialysis patients. Simultaneous administration of 8.4% sodium bicarbonate (i.v., 2 mEq/kg) for 1/2 hour and salbutamol (15 mg) in nebulized form for 10 min was compared with treatment modality of either bicarbonate or salbutamol alone. Infusion of sodium bicarbonate induced a significant rise in plasma bicarbonate from 17.3 +/- 3.2 to 22.1 +/- 2.4 mEq/L (p < 0.01), but was ineffective in lowering plasma potassium (-0.13 +/- 0.06 mEq/L). As expected, salbutamol significantly lowered plasma potassium (-0.57 +/0 0.03 mEq/L, p < 0.02 vs. basal value) in all except 2 patients. The combined regimen of bicarbonate and salbutamol to a total 9 patients including 2 patients without hypokalemic effect to salbutamol alone revealed a substantially greater fall in plasma potassium (-0.96 +/- 0.08 mEq/L, p = 0.000 vs. either drug alone) accompanied with significant increase in plasma bicarbonate and blood pH. Treatment with salbutamol or the combined regimen produced slight increases in heart rate but not in blood pressure. It is concluded that the combined regimen of bicarbonate and beta(2)-adrenergic agonist (salbutam...Continue Reading

Citations

Feb 28, 2009·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Duk-Kyung KimNam-Sik Woo
Feb 22, 2008·Journal of Veterinary Internal Medicine·S J Plunkett, M McMichael
Jan 14, 2011·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Min J BaekSangyun Kim
Jan 12, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Halima S JanjuaAndrew L Schwaderer
Mar 1, 2006·Electrolyte & Blood Pressure : E & BP·Ho-Jung Kim
Jan 14, 2004·Seminars in Dialysis·Valerie A Luyckx, Joseph V Bonventre
Jul 4, 2019·Current Opinion in Nephrology and Hypertension·Marcelo B LopesRoberto Pecoits-Filho
Mar 7, 2019·European Heart Journal Supplements : Journal of the European Society of Cardiology·Zubaid RafiqueW Frank Peacock
Aug 28, 2020·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Gregor LindnerAdam J Singer
Aug 8, 2021·The American Journal of Emergency Medicine·Shiyi GengJessica V Rivera
Jul 26, 2011·Emergency Medicine Clinics of North America·Korin B Hudson, Richard Sinert

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