Acute thiamine deficiency and refeeding syndrome: Similar findings but different pathogenesis

Nutrition
Arianna MaioranaCarlo Dionisi-Vici

Abstract

Refeeding syndrome can occur in several contexts of relative malnutrition in which an overaggressive nutritional support is started. The consequences are life threatening with multiorgan impairment, and severe electrolyte imbalances. During refeeding, glucose-involved insulin secretion causes abrupt reverse of lipolysis and a switch from catabolism to anabolism. This creates a sudden cellular demand for electrolytes (phosphate, potassium, and magnesium) necessary for synthesis of adenosine triphosphate, glucose transport, and other synthesis reactions, resulting in decreased serum levels. Laboratory findings and multiorgan impairment similar to refeeding syndrome also are observed in acute thiamine deficiency. The aim of this study was to determine whether thiamine deficiency was responsible for the electrolyte imbalance caused by tubular electrolyte losses. We describe two patients with leukemia who developed acute thiamine deficiency with an electrolyte pattern suggestive of refeeding syndrome, severe lactic acidosis, and evidence of proximal renal tubular dysfunction. A single thiamine administration led to rapid resolution of the tubular dysfunction and normalization of acidosis and electrolyte imbalance. This demonstrated ...Continue Reading

References

Dec 1, 1991·Proceedings of the Society for Experimental Biology and Medicine·M GreenJ A Arruda
Jan 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·D OriotG Huault
Oct 14, 2003·Nutrition Reviews·Mark A Marinella
Jan 29, 2008·Current Diabetes Reviews·Paul J Thornalley
Jun 28, 2008·BMJ : British Medical Journal·Hisham M MehannaJane Travis
Aug 4, 2011·International Journal of Nephrology·Francesco EmmaCarlo Dionisi-Vici
Jan 10, 2012·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Krishnan SriramKimberly Joseph

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Citations

Mar 13, 2016·Medical Hypotheses·P H SukopL V Diemen
Jul 6, 2016·Frontiers in Nutrition·Laurent HifflerDaniel Martinez Garcia
Jan 17, 2015·JPEN. Journal of Parenteral and Enteral Nutrition·Guglielmo SalvatoriAndrea Dotta
Jan 8, 2015·JPEN. Journal of Parenteral and Enteral Nutrition·Laura L Frank
Jan 16, 2019·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Bertha F PolegatoMarcos F Minicucci
Feb 8, 2020·Expert Review of Hematology·Nicola Szeja, Sebastian Grosicki
Dec 19, 2017·Current Opinion in Clinical Nutrition and Metabolic Care·Wilhelmina A C Koekkoek, Arthur R H Van Zanten
Sep 15, 2017·Annals of the New York Academy of Sciences·Laurent HifflerAviva Fattal-Vavleski
Sep 1, 2017·Annals of Neurology·Juan Darío Ortigoza-EscobarUNKNOWN Thiamine Deficiency Study Group
Sep 5, 2020·Frontline Gastroenterology·Aminda De Silva, Jeremy M D Nightingale

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