Acute thiamine deficiency and refeeding syndrome: Similar findings but different pathogenesis

Arianna MaioranaCarlo Dionisi-Vici


Refeeding syndrome can occur in several contexts of relative malnutrition in which an overaggressive nutritional support is started. The consequences are life threatening with multiorgan impairment, and severe electrolyte imbalances. During refeeding, glucose-involved insulin secretion causes abrupt reverse of lipolysis and a switch from catabolism to anabolism. This creates a sudden cellular demand for electrolytes (phosphate, potassium, and magnesium) necessary for synthesis of adenosine triphosphate, glucose transport, and other synthesis reactions, resulting in decreased serum levels. Laboratory findings and multiorgan impairment similar to refeeding syndrome also are observed in acute thiamine deficiency. The aim of this study was to determine whether thiamine deficiency was responsible for the electrolyte imbalance caused by tubular electrolyte losses. We describe two patients with leukemia who developed acute thiamine deficiency with an electrolyte pattern suggestive of refeeding syndrome, severe lactic acidosis, and evidence of proximal renal tubular dysfunction. A single thiamine administration led to rapid resolution of the tubular dysfunction and normalization of acidosis and electrolyte imbalance. This demonstrated ...Continue Reading


Dec 1, 1991·Proceedings of the Society for Experimental Biology and Medicine·M GreenJ A Arruda
Jan 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·D OriotG Huault
Oct 14, 2003·Nutrition Reviews·Mark A Marinella
Jan 29, 2008·Current Diabetes Reviews·Paul J Thornalley
Jun 28, 2008·BMJ : British Medical Journal·Hisham M MehannaJane Travis
Aug 4, 2011·International Journal of Nephrology·Francesco EmmaCarlo Dionisi-Vici
Jan 10, 2012·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Krishnan SriramKimberly Joseph

❮ Previous
Next ❯


Mar 13, 2016·Medical Hypotheses·P H SukopL V Diemen
Jul 6, 2016·Frontiers in Nutrition·Laurent HifflerDaniel Martinez Garcia
Jan 17, 2015·JPEN. Journal of Parenteral and Enteral Nutrition·Guglielmo SalvatoriAndrea Dotta
Jan 8, 2015·JPEN. Journal of Parenteral and Enteral Nutrition·Laura L Frank
Jan 16, 2019·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Bertha F PolegatoMarcos F Minicucci
Feb 8, 2020·Expert Review of Hematology·Nicola Szeja, Sebastian Grosicki
Dec 19, 2017·Current Opinion in Clinical Nutrition and Metabolic Care·Wilhelmina A C Koekkoek, Arthur R H Van Zanten
Sep 15, 2017·Annals of the New York Academy of Sciences·Laurent HifflerAviva Fattal-Vavleski
Sep 1, 2017·Annals of Neurology·Juan Darío Ortigoza-EscobarUNKNOWN Thiamine Deficiency Study Group
Sep 5, 2020·Frontline Gastroenterology·Aminda De Silva, Jeremy M D Nightingale

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Critical Care : an Official Publication, American Association of Critical-Care Nurses
Mary G Adams, Michele M Pelter
The American Journal of Nursing
M W Schwartz
The American Journal of Cardiology
Praveen VemulaGeorge S Abela
© 2021 Meta ULC. All rights reserved