Acute third ventricular administration of insulin decreases food intake in two paradigms

Pharmacology, Biochemistry, and Behavior
Ellen L AirStephen C Woods

Abstract

The pancreatic hormone, insulin, has been hypothesized to be an important regulator of food intake. Consistent with this hypothesis is the finding that exogenous insulin, in doses that do not affect blood glucose, reliably suppresses food intake and body weight. However, previous experiments have utilized a long-term delivery paradigm, in which insulin is administered via osmotic minipump and changes in body weight and food intake are measured across days. In separate experiments, we report that acute central injections of insulin can reduce food intake. In Experiment 1, injection of insulin (8 mU) into the third cerebral ventricle reliably suppressed intake of pelleted rat chow beginning at onset of the rats' dark phase. In Experiment 2, central insulin reliably and dose dependently suppressed intake of a 1-h 15% sucrose meal in the middle of the light phase. These data suggest that insulin can reduce food intake in acute delivery paradigms and provide another means by which to assess the roles of other central systems in the mediation of insulin's effects on energy homeostasis.

References

Feb 1, 1977·Journal of Comparative and Physiological Psychology·S C WoodsM V Vitiello
Feb 1, 1988·The Journal of Clinical Investigation·K S PolonskyE Van Cauter
Feb 1, 1988·The Journal of Clinical Investigation·K S PolonskyE Van Cauter
Oct 5, 1981·Life Sciences·L D McKayS C Woods
May 1, 1984·Brain Research Bulletin·D J Brief, J D Davis
Mar 1, 1981·Diabetologia·D Porte, S C Woods
Jun 1, 1995·Behavioral Neuroscience·M ChavezS C Woods
Oct 1, 1993·Appetite·T A SpiegelE Stellar
Oct 1, 1995·Physiology & Behavior·C A RiedyS C Woods
Jan 1, 1996·Neuroscience and Biobehavioral Reviews·S C WoodsR J Seeley
Dec 1, 1996·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R J SeeleyM W Schwartz
Jun 20, 1998·Science·S C WoodsM W Schwartz
Mar 14, 2000·Neuroscience and Biobehavioral Reviews·J C Smith

❮ Previous
Next ❯

Citations

Jun 23, 2011·Reviews in Endocrine & Metabolic Disorders·Stephanie Sisley, Darleen Sandoval
Jun 30, 2011·Reviews in Endocrine & Metabolic Disorders·Thomas Scherer, Christoph Buettner
Sep 8, 2012·Molecular Neurobiology·Rasoul GhasemiAbolhassan Ahmadiani
Mar 1, 2003·Frontiers in Neuroendocrinology·Kevin D Niswender, Michael W Schwartz
Nov 17, 2012·Nutrition & Diabetes·B Perry, Y Wang
Sep 13, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M HallschmidW Kern
Mar 9, 2013·Advances in Physiology Education·Denovan P Begg, Stephen C Woods
Oct 18, 2012·American Journal of Physiology. Endocrinology and Metabolism·Stephen C Woods, Wolfgang Langhans
Aug 24, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Camille B Blake, Bret N Smith
Oct 24, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dianne P Figlewicz, Stephen C Benoit
Sep 29, 2011·Journal of Obesity·Keisuke SuzukiStephen R Bloom
Apr 29, 2010·Endocrine Journal·Keisuke SuzukiStephen R Bloom
Jul 18, 2012·F1000 Biology Reports·Oksana Kaidanovich-BeilinRoger S McIntyre
Nov 14, 2013·The Journal of Endocrinology·Marc SchneebergerMarc Claret
Jan 29, 2013·Physiology & Behavior·Stephen C Woods
Jan 10, 2014·Psychopharmacology·Lourdes Valencia-TorresVladimir Orduña
Aug 18, 2012·Experimental Diabetes Research·Keisuke SuzukiStephen R Bloom
Jun 3, 2009·Archives of Physiology and Biochemistry·Zvi Laron
Jan 28, 2012·Maturitas·Angelica Lindén Hirschberg
Mar 17, 2010·Pharmacology, Biochemistry, and Behavior·Dianne P Figlewicz, Alfred J Sipols
Jun 9, 2004·Experimental Physiology·K G Murphy, S R Bloom
Sep 8, 2015·Physiology & Behavior·Eugenia Mc AllisterWolfgang Langhans
Nov 13, 2009·Journal of Animal Physiology and Animal Nutrition·J-Y SunX-Y Weng
Oct 21, 2010·The Mount Sinai Journal of Medicine, New York·Emily J GallagherEddy Karnieli
Jan 17, 2014·Journal of Neuroendocrinology·V F H JensenJ Lykkesfeldt
Sep 24, 2004·Trends in Endocrinology and Metabolism : TEM·Kevin D NiswenderMichael W Schwartz
Jul 6, 2004·Physiology & Behavior·Stephen C Woods
Sep 19, 2006·Physiology & Behavior·Lynda M BrownStephen C Woods
Jun 23, 2005·Peptides·K G Murphy, S R Bloom
Mar 1, 2005·The Psychiatric Clinics of North America·Karine Proulx, Randy J Seeley
Sep 10, 2014·Best Practice & Research. Clinical Gastroenterology·Helena BuhmannMarco Bueter
Jan 19, 2011·Physiology & Behavior·Deborah J CleggStephen C Woods

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.