PMID: 8454082Jan 1, 1993Paper

Acute thrombogenicity and 4 weeks healing properties of a new stretch-ePTFE graft

European Journal of Vascular Surgery
H PärssonL Norgren

Abstract

Recently a new expanded polytetrafluoroethylene (ePTFE) graft with length compliant characteristics has been developed. The present study compared the acute thrombogenicity and 4 weeks healing characteristics of the stretch ePTFE graft to standard ePTFE grafts in vivo. Grafts of 6 cm length and 8 mm internal diameter were inserted end-to-side into the iliac arteries in pigs. Platelet adhesion was assessed by infusing indium-111-oxine (20 MBq) labelled autologous platelets and dynamically imaging the grafts. Explanted grafts (n = 14) were opened longitudinally and the thrombus-free surface (TFS) and segmental accumulation of platelets were determined. Stretch ePTFE grafts had significantly less platelet deposition when compared to standard ePTFE graft (p < 0.01). The dynamic increase of activity from 10 min after start of measurement was also significantly reduced (p < 0.05) for 170 min as compared to standard ePTFE grafts. TFS was 68 +/- 5% for stretch ePTFE and 37 +/- 5% for standard ePTFE grafts (p < 0.01). After explanation and fixation the grafts were investigated by light microscopy, scanning and transmission electron microscopy. At 1 week after surgery, both kind of grafts were covered by a fibrinous layer containing plat...Continue Reading

References

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Citations

Dec 22, 1999·Journal of Biomedical Materials Research·R D SchaubW R Wagner
Aug 1, 1997·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·D M ShahR P Leather
Jun 1, 2000·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A OdegårdV Videm
Dec 26, 2001·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A MargovskyR S A Lord
Apr 1, 1995·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·J H TordoirP J Kitslaar

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