Acute tissue damage after injections of thrombin and plasmin into rat striatum

Stroke; a Journal of Cerebral Circulation
M Xue, M R Del Bigio

Abstract

Extravasation of blood is associated with intracerebral hemorrhage and head trauma. The mechanism of brain cell injury associated with hemorrhage differs from that due to pure ischemia. The purpose of this study was to investigate the acute changes after intracerebral injections of proteins that are involved in blood clotting and clot lysis. Sixty-eight adult rats were subjected to stereotaxic intrastriatal injections of normal saline (5 microL), low- (2.5 U/5 microL) and high-dose (25 U/5 microL) thrombin, low- (0.1 microgram/5 microL) and high-dose (1 microgram/5 microL) tissue plasminogen activator, low- (0.05 U/5 microL) and high-dose (0.5 U/5 microL) plasminogen, and low- (0.335 U/5 microL) and high-dose (3.35 U/5 microL) plasmin. Forty-eight hours later rats were perfusion fixed. Brain damage area, eosinophilic neurons, terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end labeling (TUNEL)-positive cells, infiltrating neutrophils, CD8a immunoreactive leukocytes, and reactive microglia were quantified. Damage area in striatum, dying cells, inflammatory cells, and microglial reaction were significantly greater after the high-dose plasminogen, plasmin, and thrombin injections. Tissue plasmi...Continue Reading

References

Nov 1, 1992·European Journal of Immunology·N Torres-NagelT Hünig
Oct 1, 1991·Brain Research. Molecular Brain Research·C F DeschepperM C Lapointe
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D Gurwitz, D D Cunningham
Jan 1, 1981·Annals of the New York Academy of Sciences·J W Fenton
Dec 1, 1995·Journal of Neurosurgery·K R LeeJ T Hoff
Jan 1, 1995·Brain Research Bulletin·J H WareR N Pittman
Jan 15, 1993·Brain Research·H EhrenreichP R Burd
Jan 1, 1993·Journal of Neurotrauma·A NishinoT Yoshimoto
Aug 1, 1994·Cephalalgia : an International Journal of Headache·L O CardellL Edvinsson
Apr 11, 1994·Neuroscience Letters·C S SimpsonB J Morris
Jan 1, 1994·European Neurology·G F HamannK Schimrigk
Aug 1, 1993·The Journal of Clinical Investigation·A P SappinoJ D Vassalli
Jan 1, 1996·Journal of Neurosurgery·K R LeeJ T Hoff
Aug 1, 1996·Journal of Neurosurgery·G P ColonJ T Hoff
Nov 21, 1997·Brain Research·D ArmaoG A Rosenberg
Jul 16, 1999·Neurological Research·M R Del BigioJ Peeling
Jan 5, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K BarthaR Machovich
Feb 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·F StriggowG Reiser
Feb 26, 2000·Trends in Pharmacological Sciences·T M Cocks, J D Moffatt
May 29, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D Vivien, A Buisson
Aug 15, 2000·Trends in Neurosciences·M B Gingrich, S F Traynelis

❮ Previous
Next ❯

Citations

Aug 19, 2004·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Jingxia GuanZhibin Chen
Jun 27, 2009·Clinical Reviews in Allergy & Immunology·Aviva KatzavJoab Chapman
Aug 1, 2013·Journal of Molecular Neuroscience : MN·Doron BushiDavid Tanne
May 29, 2004·Neurobiology of Aging·Molina MhatrePaula Grammas
Oct 2, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Mengzhou Xue, Marc R Del Bigio
Mar 5, 2009·Journal of Neurotrauma·Juan J HerreraPonnada A Narayana
Apr 5, 2003·Biological Chemistry·Hong Wang, Georg Reiser
Jun 1, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bo ChenPatrick D Lyden
Aug 21, 2013·International Journal of Molecular Sciences·Osvaldo MiranteLorenz Hirt
Oct 2, 2008·Neurological Research·Mengzhou Xue, V Wee Yong
Dec 20, 2013·Journal of Molecular Neuroscience : MN·Zeev ItzeksonJoab Chapman
Nov 11, 2014·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Jayalakshmi CaliaperumalFrederick Colbourne
Oct 15, 2010·The International Journal of Neuroscience·He LiDe-Sheng Wang
Oct 21, 2016·Journal of Neurotrauma·Zeev Itsekson-HayoshChaim G Pick
May 5, 2009·Annals of Medicine·Daniel StrbianPerttu J Lindsberg
Dec 17, 2015·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Serdar KayaSebahattin Cureoglu
Feb 5, 2011·Journal of Neuropathology and Experimental Neurology·Iska Moxon-Emre, Lyanne C Schlichter
Jul 15, 2011·Neuropharmacology·Masatoshi OhnishiAkinori Akaike
Oct 18, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Shinji FujimotoAkinori Akaike
Oct 7, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Xiurong ZhaoJaroslaw Aronowski
Jan 21, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Perttu Johannes LindsbergMarja-Liisa Karjalainen-Lindsberg
Jun 5, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Be'eri Niego, Robert L Medcalf
Jul 1, 2008·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Masahiko KawanishiSeigo Nagao
Dec 18, 2004·Journal of Neuroscience Research·Orit BeilinJoab Chapman
Jun 5, 2003·Annals of Neurology·Christopher PowerJames Peeling
Nov 1, 2008·The European Journal of Neuroscience·Jason K WassermanLyanne C Schlichter
Oct 10, 2006·Autoimmunity Reviews·Joab Chapman
Feb 19, 2015·Journal of Molecular Neuroscience : MN·Ze'ev Itsekson-HayoshSagi Harnof

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.