PMID: 15230330Jul 3, 2004Paper

Acute-to-chronic species sensitivity distribution extrapolation

Environmental Toxicology and Chemistry
Cédric DuboudinHélène Magaud

Abstract

Seeking to make greater use of available data for risk assessment of substances, we constructed, for the situation in which chronic data are limited or even nonexistent but acute data are relatively large, an acute to chronic transformation (ACT) methodology based on the concept of species sensitivity distributions (SSDs). This ACT methodology uses a comparison of acute and chronic SSDs, separately for vertebrate data (with 22 substances) and for invertebrate data (with 15 substances). Rather than comparing an acute toxicity value with a chronic value, as when calculating an acute to chronic ratio (ACR), samples of acute and chronic data corresponding to the same category of species were compared. Starting from a sample of acute data, the ACT methodology showed relationships that enable the creation of a sample of predicted chronic values. This sample can then be used to calculate a predicted chronic hazardous concentration potentially affecting 5% of species (HC5%), just as with a sample of real chronic toxicity values. This ACT approach was tested on 11 substances. For each substance, the real chronic HC5% and the predicted chronic HC5% were calculated and compared. The ratio between chronic HC5% and ACT HC5% was, on average,...Continue Reading

References

Jul 12, 2002·Environmental Toxicology and Chemistry·Eric P M GristMark Crane
Oct 10, 2002·Environmental Toxicology and Chemistry·Vincent BonnometBernard Beauzamy
Oct 23, 2002·Environmental Toxicology and Chemistry·James R WheelerMark Crane
Oct 26, 2002·Marine Pollution Bulletin·J R WheelerM Crane
Feb 26, 2004·Environmental Toxicology and Chemistry·Cédric DuboudinHélène Magaud

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Citations

Sep 2, 2011·Environmental Science and Pollution Research International·Xiaowei JinZijian Wang
Mar 11, 2011·Journal of Toxicology and Environmental Health. Part a·Frederik De LaenderLionel Camus
Sep 26, 2015·Environmental Science & Technology·Guillaume Kon Kam KingSandrine Charles
Feb 19, 2013·Environmental Toxicology and Chemistry·Fadri GottschalkBernd Nowack
Jul 25, 2015·PloS One·Xiaoqing WangMike J McLaughlin
Sep 20, 2019·Integrated Environmental Assessment and Management·Henning WiggerVéronique Adam
Feb 27, 2020·Environmental Toxicology and Chemistry·Yoshinari TanakaNoriyuki Suzuki
May 3, 2020·Environmental Science and Pollution Research International·Guozhu MaoFaryal Mehr

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