PMID: 9537687Apr 16, 1998Paper

Acute tolerance to the ataxic effects of ethanol in short-sleep (SS) and long-sleep (LS) mice

Psychopharmacology
Kathryn J Gill, R A Deitrich

Abstract

The objective of this series of studies was to examine the relationship between alcohol sensitivity and the development of very rapid acute tolerance to alcohol in mice. In order to measure acute tolerance to alcohol, a behavioral test was developed using a rotorod. In the first study, mice selectively bred for resistance (short sleep, SS) or sensitivity (long sleep, LS) to the acute hypnotic effects of ethanol were used, as well as mice from the base population (heterogeneous stock, HS). Mice were trained to run on the rotorod at a speed of 14 rpm to a criterion of 200 s, in four daily training sessions. On the test day, baseline measurements of rotorod performance were taken and mice were injected i.p. with alcohol in doses from 0 to 2.5 g/kg. Animals were tested at 1-min intervals for the first 5 min following injection, then at 5-min intervals for a total of 30 min. The results demonstrated that SS and HS mice developed tolerance within 10 min following the alcohol injections. LS mice did develop some acute tolerance, but at a much slower rate than the SS or HS mice. In the second study, the effects of intoxicated practice on the rates of acute tolerance development were examined in the SS, HS and LS mice at a dose of 2.0 g...Continue Reading

Citations

Jun 17, 2010·Behavior Genetics·John C CrabbeJohn K Belknap
Aug 31, 2001·Pharmacology, Biochemistry, and Behavior·N J GrahameL Lumeng
Nov 10, 2001·Pharmacology, Biochemistry, and Behavior·L J DraskiR A Deitrich
Oct 16, 2008·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Chris DowningDavid Gilliam
Jun 1, 2000·Alcoholism, Clinical and Experimental Research·V M Gehle, V G Erwin
Jan 26, 2007·Alcoholism, Clinical and Experimental Research·Beth BennettThomas E Johnson
Nov 5, 2005·Alcoholism, Clinical and Experimental Research·Heather M HaugheyNancy R Zahniser
Nov 5, 2005·Alcoholism, Clinical and Experimental Research·Robert C Ristuccia, Linda P Spear
Jul 15, 2004·Alcoholism, Clinical and Experimental Research·Igor Ponomarev, John C Crabbe
Jun 18, 2004·Alcoholism, Clinical and Experimental Research·M M Silveri, L P Spear
May 17, 2008·Alcoholism, Clinical and Experimental Research·Melanie L SchwandtChristina S Barr
Oct 28, 2006·Alcoholism, Clinical and Experimental Research·Elena I Varlinskaya, Linda P Spear
Feb 9, 2012·Alcoholism, Clinical and Experimental Research·John C CrabbePamela Metten
Jul 28, 2011·Alcoholism, Clinical and Experimental Research·Amul J SakharkarSubhash C Pandey
Feb 12, 2014·Alcoholism, Clinical and Experimental Research·Jonathan H LindsayRebecca A Prosser
Sep 11, 2009·Alcoholism, Clinical and Experimental Research·Rebecca A Prosser, J David Glass
Jun 18, 2002·The Journal of Pharmacology and Experimental Therapeutics·Igor Ponomarev, John C Crabbe
Oct 2, 2019·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·Eetmad A Arafat, Dalia A Shabaan

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