Acute Toxicity From Breast Cancer Radiation Using Helical Tomotherapy With a Simultaneous Integrated Boost

Technology in Cancer Research & Treatment
Andrzej P WojcieszynskiPoonam Yadav

Abstract

To evaluate 2 simultaneous integrated boost treatment planning techniques using helical tomotherapy for breast conserving therapy with regard to acute skin toxicity and dosimetry. Thirty-two patients were studied. The original approach was for 16 patients and incorporated a directional block of the ipsilateral lung and breast. An additional 16 patients were planned for using a modified approach that incorporates a full block of the ipsilateral lung exclusive of 4 cm around the breast. Dose-volume histograms of targets and critical structures were evaluated. Skin toxicity monitoring was performed throughout treatment and follow-up using the Common Terminology Criteria for Adverse Events. Treatment was well tolerated with patients receiving a median dose of 59.36 Gy. Of the 16 patients in both groups, 8 had grade 2 erythema immediately after radiation. On 3-week follow-up, 10 and 7 patients in the original and modified groups showed grade 1 erythema. On 3- and 6-month follow-up, both groups had minimal erythema, with all patients having either grade 0 or 1 symptoms. No grade 2 or 3 toxicities were reported. Mean treatment time was 7.5 and 10.4 minutes using the original and modified methods. Adequate dose coverage was achieved us...Continue Reading

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Citations

Sep 7, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Rosalinda RicottiBarbara Alicja Jereczek-Fossa
Jan 29, 2017·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Poonam YadavAnna Olson
Dec 6, 2018·Cancer Investigation·Valentina LancellottaCynthia Aristei
Aug 27, 2019·Tumori·Rosalinda RicottiBarbara Alicja Jereczek-Fossa

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Software Mentioned

CTCAE
TomoTherapy
STATA
TomoTherapy TPS

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