Acute toxicity of citrinin in turkeys and ducklings

Avian Pathology : Journal of the W.V.P.A
N A MehdiJ Tuite

Abstract

Citrinin, a naturally occurring mycotoxin, was dissolved in dimethyl-sulphoxide - 70% ethanol (3:1, v/v) and administered orally in two trials to 7-day-old male turkey poults and male white Pekin ducklings. The single dose LD50 value in 7-day-old male turkey poults was 56 mg/kg and in 7-day-old male white Pekin ducklings it was 57 mg/kg. The mycotoxin was nephrotoxic in both species, but the renal lesions were more severe in turkeys and were characterised by degeneration and necrosis of renal tubular epithelium. In turkeys, lesions were found in the liver and included hepatic cell necrosis and biliary hyperplasia. Lymphoid necrosis with depletion involved the thymus and cloacal bursa of turkeys and ducklings. These latter lesions were the most prominent histopathological alterations in citrinin-treated ducklings.

References

Mar 1, 1979·Toxicology·R D PhillipsA W Hayes
Dec 1, 1977·Food and Cosmetics Toxicology·G Sansing
Jan 1, 1978·Toxicon : Official Journal of the International Society on Toxinology·R D Phillips, A W Hayes
Aug 1, 1978·Food and Cosmetics Toxicology·W H Jordan, W W Carlton
Oct 1, 1978·Food and Cosmetics Toxicology·W H JordanG Sansing
Feb 1, 1977·Food and Cosmetics Toxicology·W H JordonG Sansing
Aug 1, 1974·Food and Cosmetics Toxicology·W W CarltonJ Tuite
Sep 1, 1981·Poultry Science·T S NelsonM M Campbell
Dec 1, 1981·Food and Cosmetics Toxicology·N A MehdiJ Tuite
Nov 1, 1980·Kidney International·W O BerndtR D Phillips

Citations

Dec 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C HanikaJ Tuite
Jan 1, 1988·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·C M Czarnecki
Jan 1, 1984·Avian Pathology : Journal of the W.V.P.A·N A MehdiJ Tuite
Jan 12, 2010·Arhiv za higijenu rada i toksikologiju·Dubravka Flajs, Maja Peraica
Nov 26, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Han QingqingLiu Shuqiang
Sep 13, 2017·Journal of the Science of Food and Agriculture·Nurshad Ali
May 1, 1986·Veterinary Pathology·C HanikaJ Tuite

Related Concepts

Ethanol
Citrinin
Clinical Trials
Dimethyl Sulfoxide
Liver
Mycotoxins
Necrosis
Nerve Degeneration
Thymus Gland
Meleagridinae

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