Acute toxicity of high-dose-rate intracavitary brachytherapy with the MammoSite applicator in patients with early-stage breast cancer

Annals of Surgical Oncology
Gregory M RichardsChristopher Mills

Abstract

Intracavitary brachytherapy with the MammoSite applicator as the sole radiation treatment in breast-conserving therapy is an option for women with early-stage breast cancer; we evaluated the acute toxicities associated with this treatment method. Thirty-one patients with 32 stage I or II breast carcinomas underwent breast-conserving therapy, which included lumpectomy with negative margins, sentinel node biopsy, or axillary dissection, followed by brachytherapy with the MammoSite applicator. Acute radiation skin complications were graded on the day of radiotherapy completion and at weeks 2, 4, 6, and 12 after radiation treatment. Cosmesis was graded on the Harvard Scale at all follow-ups. The median follow-up was 11 months (range, 4-15 months). Twenty-seven of the 31 patients were treated with the device as the sole method of radiotherapy. No acute toxicities occurred during the 5 days of treatment. Nineteen patients (68%) had no to mild acute skin reactions, and 25% developed bright erythema and patchy moist desquamation. Two patients (7%) developed confluent moist desquamation within the first 4 weeks (grade 3); this healed by week 12. All skin reactions were localized to the area overlying the balloon. Sixteen percent (5 of 3...Continue Reading

References

Jan 18, 1990·The New England Journal of Medicine·R PlattK F Holbrook
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·J D CoxT F Pajak
May 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R ArriagadaG Contesso
Mar 21, 1998·American Journal of Infection Control·M L BertinS M Gordon
Mar 24, 1998·Journal of the American College of Surgeons·M MorrowA Rademaker
Nov 7, 1998·BMJ : British Medical Journal·N BundredA Baildam
Apr 3, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F A ViciniA Martinez
Apr 17, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M MorrowD Winchester
Apr 24, 2001·International Journal of Radiation Oncology, Biology, Physics·D E WazerT A DiPetrillo
Jun 29, 2001·International Journal of Radiation Oncology, Biology, Physics·K L BaglanF A Vicini
Sep 6, 2001·Journal of the National Cancer Institute·A B NattingerM A Gilligan
Apr 18, 2002·International Journal of Radiation Oncology, Biology, Physics·Gregory K EdmundsonAlvaro A Martinez
Mar 26, 2003·Zentralblatt für Gynäkologie·A NietoC Carralafuente
Aug 21, 2003·Journal of the National Cancer Institute·Frank A ViciniAlvaro Martinez
Oct 14, 2003·American Journal of Surgery·Victor J ZannisCoral A Quiet
Jan 7, 2004·World Journal of Surgery·Diana Vilar-Compte, Mauricio García Saenz
Feb 13, 2004·World Journal of Surgery·Diana Vilar-ComptePatricia Volkow
Apr 6, 2004·Brachytherapy·Douglas W ArthurUNKNOWN American Brachytherapy Society
Apr 13, 2004·Annals of Surgery·Henry M KuererFrank A Vicini

❮ Previous
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Citations

Oct 1, 2010·Medical Physics·Susan L Richardson, Ramiro Pino
May 10, 2011·OncoTargets and Therapy·William C DooleyCharles A Lee
Nov 3, 2005·Nature Clinical Practice. Oncology·Rajiv Sarin
Jul 14, 2004·Annals of Surgical Oncology·Douglas W Arthur, Frank A Vicini
Feb 9, 2006·Current Oncology Reports·Alphonse G Taghian, Abram Recht
Mar 15, 2016·International Journal of Radiation Oncology, Biology, Physics·Jinhai HuoGrace L Smith
Jan 12, 2016·Journal of Surgical Oncology·Maoz ZurMariana Steiner
Apr 5, 2011·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Sharon M LuCatheryn Yashar
Jun 24, 2009·International Journal of Radiation Oncology, Biology, Physics·Benjamin D SmithJay R Harris
Jul 28, 2009·Journal of the American College of Surgeons·Benjamin D SmithJay R Harris
Jan 27, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jonathan B Strauss, Adam Dickler
Oct 28, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Daniel J ScanderbegTodd Pawlicki
Aug 4, 2009·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Aime GloiGreg Cooley
Sep 12, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Birgitte V OffersenJens Overgaard
Apr 15, 2008·International Journal of Radiation Oncology, Biology, Physics·Yongbok KimMoyed Miften
Nov 27, 2007·International Journal of Radiation Oncology, Biology, Physics·Laurie W CuttinoDouglas W Arthur
Jan 27, 2007·Current Problems in Cancer·Gregory M Chronowski, Thomas A Buchholz
May 30, 2006·Hematology/oncology Clinics of North America·Jennifer R BellonAlphonse Taghian
Jan 15, 2009·The Breast Journal·Peter D BeitschRakesh R Patel
Jun 20, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Peter NiehoffGyörgy Kovács
May 30, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Tibor MajorCsaba Polgár
Sep 27, 2005·Brachytherapy·Vijay Kini
Aug 12, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Yazid BelkacémiEric Lartigau
Oct 24, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carolyn J PresleyCary P Gross
Mar 10, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Douglas W Arthur, Frank A Vicini
Feb 19, 2009·Journal of Applied Clinical Medical Physics·Chang Hyun ChoiRoger Ove
Nov 6, 2007·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·Y BelkacémiJ-B Dubois
Aug 30, 2005·Journal of the American College of Surgeons·Kelly M McMasters
Apr 7, 2007·American Journal of Clinical Oncology·Atilla SoranJeffrey S Falk
May 31, 2007·Nature Clinical Practice. Oncology·Adam Dickler, Atif J Khan
Apr 9, 2010·American Journal of Clinical Oncology·Vivek K MehtaThomas W Rusch
Nov 19, 2005·Expert Review of Medical Devices·Martin Keisch
Oct 6, 2006·Expert Review of Anticancer Therapy·Michael S Sabel

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