Acute toxicological effects on the earthworm Eisenia fetida of 18 common pharmaceuticals in artificial soil

The Science of the Total Environment
Ma Rosa PinoElisa Langa

Abstract

Following soil applications of recycled water and biosolids, pharmaceutical residues can eventually enter the terrestrial environment. In vitro and in vivo assays have largely focused on the acute ecotoxicity of these compounds in aquatic systems. However, studies on the ecotoxicological effects of pharmaceuticals in soil biota are especially scarce. The aim of this study was to investigate the acute toxicity of 18 pharmaceuticals (4 NSAIDs, 5 blood lipid-lowering agents, 6 β-blockers and 3 antibiotics) that are usually found in the environment by using an Eisenia fetida bioassay. In addition, the presence of these pharmaceuticals in artificial soil was verified at the end of the test. Our results indicate that seven of the studied drugs cause acute adverse effects in E. fetida, in particular, the NSAIDs and the blood lipid-lowering agents. Ibuprofen (LC50=64.80 mg/kg) caused the highest acute toxicity for all tested compounds, followed by diclofenac (LC50=90.49 mg/kg) and simvastatin (LC50=92.70 mg/kg). Other tested pharmaceuticals from NSAIDs and blood lipid-lowering families have toxicity effects, from a LC50=140.87 mg/kg for gemfibrozil to 795.07 mg/kg for lovastatin. Atorvastatin, bezafibrate, β-blockers and antibiotics sh...Continue Reading

References

Feb 1, 1990·Digestive Diseases and Sciences·F M GiardielloJ H Yardley
Dec 11, 1999·Environmental Health Perspectives·C G Daughton, T A Ternes
Jun 25, 2003·Chemosphere·Luciana MiglioreMaurizio Fiori
Nov 17, 2004·Environmental Science & Technology·Thomas A TernesHansruedi Siegrist
Jan 14, 2005·Journal of Environmental Quality·Kang XiaGreg Pillar
Jun 7, 2005·The Science of the Total Environment·Paul H Roberts, Kevin V Thomas
Aug 9, 2005·Environmental Science & Technology·Dirk LöfflerThomas A Ternes
Oct 14, 2005·Journal of Environmental Quality·K KumarC J Rosen
Mar 8, 2006·Environmental Toxicology and Chemistry·Chad A KinneyJeffery D Cahill
Mar 16, 2006·Journal of Agricultural and Food Chemistry·Alistair B A BoxallLen S Levy
Aug 11, 2006·Journal of Environmental Quality·C F WilliamsF J Adamsen
Oct 13, 2006·Environmental Pollution·W D KongM Yang
Oct 13, 2006·Analytical and Bioanalytical Chemistry·Mechthild Schmitt-JansenRolf Altenburger
Dec 19, 2006·Ecotoxicology and Environmental Safety·F FourieA J Reinecke
Jun 29, 2007·Journal of Environmental Quality·Holly DolliverSatish Gupta
Aug 7, 2007·Chemosphere·Shai MarkmanCarsten T Müller
Jan 12, 1934·Science·C I Bliss
Jan 19, 2008·Environmental Science & Technology·Gerald T AnkleyJohn P Sumpter
Jan 22, 2008·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Brigida D'AbroscaPietro Monaco
Apr 2, 2008·The Science of the Total Environment·Edward ToppChris D Metcalfe
Jul 22, 2008·The Science of the Total Environment·Dele StültenMichael Spiteller
Sep 20, 2008·Environmental Science & Technology·Jochen Heidler, Rolf U Halden
Mar 3, 2009·The Science of the Total Environment·Alessandra D CoelhoMárcia Dezotti

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Citations

Aug 21, 2015·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Fanxing ZengNiels C Bols
Jun 13, 2016·Chemosphere·Diana RedeCristina Delerue-Matos
Aug 25, 2016·Environmental Science and Pollution Research International·Ma Rosa PinoEnrique Navarro
Jun 18, 2017·Environmental Geochemistry and Health·Tatiane Medeiros MeloJörg Rinklebe
Aug 8, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yao FengZhao-Jun Li
Aug 27, 2019·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Vassilis D LitskasDimitris S Koveos
May 24, 2020·Environmental Pollution·Sophie BertinBruce Petrie
Mar 15, 2021·Journal of Environmental Management·María Rosa Pino-OtínDiego Ballestero
Feb 17, 2021·Environmental Toxicology and Chemistry·Diogo N CardosoSusana Loureiro
Jul 13, 2021·Journal of Environmental Management·Ketelen Michele Guilherme de OliveiraDaniela Morais Leme
Aug 3, 2019·Environmental Science & Technology·Hong-Tao WangXi-Mei Xue

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