Acute trajectories of neural activation predict remission to pharmacotherapy in late-life depression

NeuroImage. Clinical
H T KarimHoward J Aizenstein

Abstract

Pharmacological treatment of major depressive disorder (MDD) typically involves a lengthy trial and error process to identify an effective intervention. This lengthy period prolongs suffering and worsens all-cause mortality, including from suicide, and is typically longer in late-life depression (LLD). Our group has recently demonstrated that during an open-label venlafaxine (serotonin-norepinephrine reuptake inhibitor) trial, significant changes in functional resting state connectivity occurred following a single dose of treatment, which persisted until the end of the trial. In this work, we propose an analysis framework to translate these perturbations in functional networks into predictors of clinical remission. Participants with LLD (N = 49) completed 12-weeks of treatment with venlafaxine and underwent functional magnetic resonance imaging (fMRI) at baseline and a day following a single dose of venlafaxine. Data was collected at rest as well as during an emotion reactivity task and an emotion regulation task. Remission was defined as a Montgomery-Asberg Depression Rating Scale (MADRS) ≤10 for two weeks. We computed eigenvector centrality (whole brain connectivity) and activation during the emotion regulation and emotion re...Continue Reading

Citations

Apr 30, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Katharine DunlopJonathan Downar
Aug 15, 2019·Current Psychiatry Reports·Katharine DunlopConor Liston
Sep 4, 2019·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Carmen AndreescuWarren D Taylor
Jan 30, 2021·Frontiers in Psychiatry·Gabriele SaniBernardo Carpiniello
Nov 30, 2020·The International Journal of Neuropsychopharmacology·Ana Maria Rivas-GrajalesSanjay J Mathew
Jul 27, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Jennifer I LissemoreDaniel M Blumberger

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BETA
PCA
pharmacotherapies

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Psychology
MATLAB
FastECM
ArtRepair
SPM12
prime

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